Secondary Prevention of Stroke Through Non-drug Therapeutic Weight Reduction "SCENARIO"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Diagnosis of ischemic stroke
- Age: 20 - 85 years
- BMI ≥ 25.0 kg/m² or waist circumference in men ≥ 94cm and in women ≥ 80cm
- Functional impairment, which would allow to participate in weight reduction program (mRS 0-4, NIHSS 0-12)
- Patient must be capable of understanding informed consent
- Written informed consent for participation in the study

Exclusion Criteria

- Intracerebral hemorrhage as primary cause of stroke (secondary hemorrhage is not an exclusion criterion)
- Speech disturbance (aphasia or sever dysarthria)
- Dimming of consciousness
- Stroke due to arterial dissection or coagulation disorder
- Drug-related weight changes during previous 3 months
- Changes in appetite influencing medication listed in appendix during previous 3 months
- Bariatric surgery in the past
- Diabetes mellitus with a history of severe ketoacidosis
- Pregnancy or nursing
- Severe co-morbid disorders, e.g.:
- AV-Block ≥ 2nd degree
- Heart insufficiency (NYHA > 2)
- Pericarditis, pericardial effusion
- Severe kidney insufficiency (Creatinine > 3 mg/dl; Urea > 150 mg/dl)
- Hepatic insufficiency (GOT > 3 x ULN; GPT > 3 x ULN)
- Severe psychiatric disease within the last six months (psychosis, suicide attempts)
- Chronic alcohol addiction or drug addiction
- HIV- or hepatitis infection
- Bleeding peptic ulcer (unless there is radiological evidence of healing 6 months prior to start of obesity program)
- Cognitive impairment with MMSE < 20
- Depression with BDI > 20
- Patients who are unable to give consent to study participation (MMSE < 20, aphasia)
- Recurrent stroke or myocardial infarction in the period between screening for study participation and start of weight reduction program
- Simultaneous participation in another clinical trial