To investigate the effect of minidose warfarin alone and in combination with aspirin in patients with chronic nonvalvular atrial fibrillation.
- Aspirin (stroke prevention) Drug
Intervention Desc: Antiplatelet agent; inhibits thromboxane A2
- Warfarin (Coumadin®)Drug
Other Names: Coumadin Intervention Desc: Anticoagulant (Vitamin K antagonist)
Randomized, controlled trial of 677 patients at a single center.
Patients were assigned to receive warfarin sodium (1.25 mg/d), warfarin sodium (1.25 mg/d) plus aspirin (300 mg/d), aspirin (300 mg/d), or adjusted-dose warfarin with an INR of 2.0 to 3.0.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Stroke or a systemic thromboembolic event.|
|Secondary||Transient ischemic attack, acute myocardial infarction, and death.|