Searching for Explanations for Cryptogenic Stroke in the Young: Revealing the Etiology, Triggers, and Outcome "SECRETO"

Recruiting

Phase N/A Results N/A

Eligibility Criteria

PATIENTS:

Inclusion Criteria

1. Age 18 to 49 at stroke onset
2. Patient hospitalized due to first-ever imaging-positive ischemic stroke of undetermined etiology after complete timely diagnostic testing.

Exclusion Criteria

1. Baseline mandatory tests not obtained in the first week following stroke onset, including:
- Brain MRI
- Routine blood tests, including complete blood count with differential, CRP, fasting glucose, creatinine, aPTT, INR, total cholesterol, LDL-cholesterol, HDL-cholesterol, HbA1C,hemoglobin electrophoresis in individuals of African origin
2. Other baseline mandatory tests not obtained within the first two weeks following stroke onset, including:
- Imaging of cervicocephalic arteries by CTA, MRA, or catheter angiography
- Transesophageal (highly recommended) or transthoracic echocardiography
- 24-hour Holter monitoring
- Screening for thrombophilia, including antiphospholipid antibodies and other coagulopathies (any abnormal finding must be retested at mandatory 3-month follow-up visit >12 weeks from initial testing or >4 weeks after cessation of anticoagulation at any later time point); mandatory tests include anticardiolipin antibodies, lupus anticoagulant, anti-β2-glycoprotein antibodies, factor V mutation (or aPC resistency ruled out), factor II mutation, homocysteine, antithrombin III, protein C, and protein S
3. No evidence of current brain ischemia
4. Current stroke due to cerebral venous thrombosis or as a complication of subarachnoid hemorrhage, angiography, or cardiac surgery
5. Patient otherwise not eligible for the study or adherent for follow-up (eg nonresident) or has concurrent disease affecting outcome (eg. multiple sclerosis, cancer)
6. Informed consent not obtained from the patient or a proxy.
CONTROL SUBJECTS:
Inclusion Criteria:
1. Age 18 to 49 years
2. Absence of prior ischemic stroke as ascertained using the Questionnaire for Verifying Stroke-Free Status
Exclusion Criterion:
1. Informed consent not obtained