The purpose of the study is to evaluate the effect of Melatonin (in a dosage of 14mg daily) for a better clinical outcome in the period three days post stroke.
Stroke is the third most common cause of stroke. The cascade of event is separated into hyperacute,,acute,sub-acute and chronic. In the acute, sub acute state there are mechanisms of inflammation apoptotic death and effect of free radicals. Melatonin was proved to effect these mechanisms and to have a favourable effect in different diseases. The aim of the study is to prove That the use of Melatonin in a higher dosage may have a anti-destructive effect in stoke.
- Placebo Drug
ARM 1: Kind: Experimental Label: sugar pill Description: sugar pill given over 14 days
- Melatonin Drug
Other Names: Melatonin Intervention Desc: none ARM 1: Kind: Experimental Label: Melatonin Description: Melatonin 14mg/daily given over 14 days
- Allocation: Randomized
- Masking: Double Blind (Subject, Investigator, Outcomes Assessor)
- Purpose: Treatment
- Endpoint: Efficacy Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Improvement of at least one point on the MRS score||3 months||No|