Safety Study of Dantrolene to Treat Cerebral Vasospasm After Subarachnoid Hemorrhage

Completed

Phase 1/2 Results

Summary of Purpose

Subarachnoid hemorrhage (SAH) is a devastating acute brain injury due to bleeding onto the brain surface from a ruptured aneurysm. Cerebral vasospasm (cVSP; critical narrowing of brain arteries) is a known complication after SAH and significantly increases disability and death after SAH. Vasospasm is difficult to treat and can lead to stroke. Animal studies have shown that the muscles in the artery wall play a...

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 25 April 2012.

1 Jul 2007 23 Aug 2009 1 Oct 2009 1 Oct 2009 1 Apr 2012 18 Nov 2011
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Non-Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Single Group Assignment

Contacts

  • Bridget Garland, RN BDepartment of Neurology University of Massachusetts, Medical School University Campus, 55 Lake Avenue North, Worcester, MA 01655 Tel: 508-856-4667 Fax: 508-856-4675 Pager: [internal] #9633, [external] 508-426-1458 E-mail: bridget.garland@umassmed.edu Department of Neurology University of Massachusetts, Medical School University Campus, 55 Lake Avenue North, Worcester, MA 01655 Tel: 508-856-4667 Fax: 508-856-4675 Pager: [internal] #9633, [external] 508-426-1458 E-mail: bridget.garland@umassmed.edu

    susanne.muehlschlegel@umassmemorial.org