Safety Study of Dantrolene in Subarachnoid Hemorrhage


Phase 1/2 Results

Eligibility Criteria

Inclusion Criteria

- Documented aneurysmal SAH by computed tomography angiography (CTA), magnetic resonance angiography (MRA) or angiography
- Secured aneurysm (coiled or clipped)
- Enrollment achievable within 14 days after SAH

Exclusion Criteria

- Pregnancy
- Prior history of cirrhosis or hepatitis B/C, or any two of the following three liver enzymes elevated to greater than: ALT >120 Units/L, AST >120 Units/L, alkaline phosphatase >345 Units/L (three times upper limit of normal)
- Patients on verapamil
- Patients with brain edema and/or elevated intracranial pressure (>25mm Hg)
- Patients treated with hypertonic saline or mannitol prior to enrollment
- Patients with too severe SAH with low likelihood of survival (Hunt & Hess 5)