Safety of Lysis with EKOS Ultrasound in the Treatment of Intracerebral and Intraventricular Hemorrhage "SLEUTH"

Active, not recruiting

Phase N/A Results


This demonstrated that administration of 1 mg of tPA every 8 hours to a maximum of 4 days was effective in evacuating intracerebral clots and reduced expected mortality by 70%. The age of the patients ranged from 38 to 83 years (mean age, 63 years); 6 were male and 3 female. All had symptoms for <12 hours before diagnostic CT scan and had spontaneous ICH >25 mL and/or IVH obstructing the third and/or fourth ventricles. Of the 9 patients in the study, 1 died and 1 with ICH was excluded from the final analysis because of a catheter breakage. At 30-day follow-up, researchers observed a significant reduction in NIHSS scores with an average overall decrease of 8.5 points — from 17 at baseline to 8.5 at 30 days