Safety and Tolerability of GV150526 in Patients With Acute Stroke


Phase 2 Results

Summary of Purpose

To assess the safety, tolerability, and pharmacokinetics of loading and maintenance infusions of GV150526 in patients with acute stroke.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 19 July 2001.

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Start Date First Received 1st Completion Completion Verification Results

Trial Basics



  • Glaxo Wellcome, Research Triangle, NC

Trial Design

Randomized, placebo-controlled, parallel-group, ascending-dose study conducted in 2 phases. In part A of the study, loading doses of 50, 100, 200, 400, or 800 mg were administered. In part B, the maximum loading dose from part A was followed by maintenance infusions (5 infusions at 12-hour intervals), aiming to maintain neuroprotective levels. The trial included 66 patients.


  • Dr A.G. Dyker, University Department of Medicine and Therapeutics, Western Infirmary, Glasgow G11 6NT, Scotland.