Robotic Pedaling Therapy for Targeted Neural Plasticity

Not yet recruiting

Phase N/A Results N/A

Eligibility Criteria

Patients:
Inclusion criteria:
- Subjects will be stroke patients with persistent moderate unilateral lower extremity deficits, age 50-85 years at time of enrollment.
- Time since stroke will be greater than 6 months ("chronic" stroke survivors).
- Persistent moderate unilateral lower-limb impairment (defined as NIH Stroke Scale - Motor Leg section score of 1-2, to be discussed with the patient verbally during phone screening and assessed by the investigator during the initial enrollment visit).
- Fluent in spoken and written English
Exclusion criteria:
- Allergy to electrode gel, surgical tape and metals.
- Subjects under treatment for infectious diseases will be excluded from the study.
- Women who are pregnant or planning to become pregnant during the course of the study will be excluded.
- Contraindications for MRI
- Age over 85 years at time of enrollment.
Healthy Controls:
Inclusion criteria:
- Ages 18-85 years
- Non-Stroke Group 1 ("Matched Controls"): 50-85 years old at time of enrollment, to match the population of stroke patients to be studied
- Non-Stroke Group 2 ("Pilot Controls"): 18-50 years old at time of enrollment (Pilot subjects to be initially enrolled early in the design phase of the study, and with enrollment ongoing throughout the study to continue development.)
- No known neurologic, psychiatric or developmental disability.
- Fluent in spoken and written English
Exclusion criteria:
- Allergy to electrode gel, surgical tape, and metals.
- Subjects under treatment for infectious diseases will be excluded from the study.
- Women who are pregnant or planning to become pregnant during the course of the study will be excluded.
- Contraindications for MRI
- Age over 85 years at time of enrollment.