Revive AIS Patients ImmeDiately "RAPID"

Recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

1. age over 18 years;
2. clinical diagnosis should be acute ischaemic stroke;
3. no more than 6 hours after onset;
4. IV tPA thrombolysis, if needed, should start within 4.5 hours after onset;
5. Pre-stroke mRS ≤2;
6. ICA/M1/M2/A1/A2/VA/BA occlusion confirmed by CTA/MRA/DSA;'
7. written informed consent form given

Exclusion Criteria

1. . history of intracranial hemorrhage.
2. . life expectancy <90 days;
3. . history of major surgery or severe trauma in the past 10 days;
4. . Uncontrolled hypertension (defined as: SBP>185mmHg or DBP ≥110 mm Hg at 3 continuous measurements with interval of at least 10 minutes confirm the SBP>185mmHg or DBP ≥110 mm Hg)
5. . PLT<40*10^9/L;
6. . blood glucose <2.7mmol /L or >22. 2 mmol /L;
7. . concomitant use of oral anticoagulation drugs, and INR >3.0;
8. . ASPECTS score ≤5;
9. . conventional angiography indicates poor collateral circulation (ACG Score ≤ 1).