The purpose of this study is to determine whether reducing a patients body temperature (mild hypothermia of 33 degrees Centigrade) will significantly reduce the risk of brain injury (notably reperfusion injury and hemorrhagic conversion) in patients that have suffered a significant interruption of blood flow to an area of brain (occlusion of large proximal cerebral artery) and have undergone successful removal of that interruption (revascularization).
- Zoll- Coolgaurd 3000 Device
Intervention Desc: Goal temperature of 33 degrees Centigrade for a duration of 12 hours and then actively rewarmed by 0.2 degrees Centigrade per hour. ARM 1: Kind: Experimental Label: Mild Hypothermia Description: Reduction of body temperature to 34 degrees centigrade.
- Masking: Open Label
- Purpose: Treatment
- Endpoint: Safety Study
- Intervention: Single Group Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Reperfusion Injury \ Hemorrhagic transformation||24 Hours||Yes|
|Secondary||National Institute of Health Stroke Scale||participants will be followed for the duration of hospital stay, an expected average of 7 dayss||No|
|Secondary||Modified Rankin Scale||90 days post hospitalization||No|
|Primary||Number of Participants With Reperfusion Injury \ Hemorrhagic Transformation||24 Hours||Yes|
|Secondary||Modified Rankin Scale 0-2||90 days post hospitalization||No|
- Emory University Lead