Remote Ischemic Limb Preconditioning In Healthy Volunteers

Recruiting

Phase N/A Results N/A

Trial Description

The investigators would like to determine if remote ischemic leg preconditioning in healthy volunteers improves cerebral vasomotor reactivity as measured by breath holding and transcranial doppler vasomotor reactivity.

Detailed Description

This study is to determine if remote ischemic leg preconditioning improves short and long term cerebral vasomotor reactivity in healthy volunteers as measured by breath holding and transcranial doppler vasomotor reactivity. Previous studies on brachial vasomotor reactivity have shown a beneficial effect of remote ischemic preconditioning. It remains uncertain if a similar beneficial effect can be reproduced with cerebral vasomotor testing. Many biological mechanisms and effector pathways triggered by preconditioning have demonstrated endothelial protection and beneficial vascular effects.

Conditions

Interventions

  • 4x 5min Limb Preconditioning Procedure
    Intervention Desc: A blood pressure cuff is placed over the upper thigh of the participant(s) and inflated to 30 millimeters of mercury (mmHg) above systolic blood pressure. The loss of pedal pulses is confirmed by palpation. The cuff remains inflated for 5min and is followed by 5 minutes of reperfusion/rest. This will be repeated 4 times.
    ARM 1: Kind: Experimental
    Label: 4x 5min Limb Preconditioning
    Description: Either the right or left leg will be made transiently ischemic for 5 minutes following by 5 minutes of rest. This will be repeated for 4 times.
  • 3x 10min Limb Preconditioning Procedure
    Intervention Desc: A blood pressure cuff is placed over the upper thigh of the participant(s) and inflated to 30 mmHg above systolic blood pressure. The loss of pedal pulses is confirmed by palpation. The cuff remains inflated for 10min and is followed by 5 minutes of reperfusion/rest. This will be repeated 3 times.
    ARM 1: Kind: Experimental
    Label: 3x 10min Limb Preconditioning
    Description: Either the right or left leg will be made transiently ischemic for 10 minutes following by 5 minutes of rest. This will be repeated for 3 times.
  • 3x 10min Sham Preconditioning Procedure
    Intervention Desc: A blood pressure cuff is placed over the upper thigh of the participant(s) and inflated to 40 mmHg, sufficient to apply pressure but not affect blood flow. The presence of pedal pulses is confirmed by palpation. The cuff remains inflated for 10min and is followed by 5 minutes of rest. This will be repeated 3 times.
    ARM 1: Kind: Experimental
    Label: 3x 10min Sham Preconditioning
    Description: Either the right or left leg will be squeezed without causing ischemia for 10 minutes following by 5 minutes of rest. This will be repeated for 3 times.

Trial Design

  • Allocation: Randomized
  • Masking: Single Blind (Subject)
  • Endpoint: Safety/Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Cerebral Vasomotor Reactivity 24 hours No

Sponsors