Remote Ischaemic Conditioning in Endovascular Recanalization for Proximal Anterior Circulation Occlusion Study "RICE PAC"

Not yet recruiting

Phase 1 Results N/A

Eligibility Criteria

Inclusion Criteria

- Acute, symptomatic proximal anterior circulation occlusion
- able to commence remote ischaemic conditioning within 6h of symptom onset
- identified as candidate for endovascular intervention according to local criteria

Exclusion Criteria

- Age < 18 years
- Coagulopathy; International Normalised Ratio (INR) >2, alteplase dose > 90mg or 0.9mg/kg; platelet count < 50 x 10^9/L
- pregnancy
- BP >= 185/110 despite therapeutic intervention
- medical illness which interferes with outcome assessments (disability from other neurological disease)
- dependent on others for activities of daily living (ADLs) prior to current stroke (mRS modified Rankin Score was 3 - 5).
- unlikely to be able to participate in study follow-up procedures (lives > 100 miles away; no fixed abode)
- already enrolled in another clinical trial involving investigational medicinal product or device
- baseline scan demonstrating significant prior infarction in the affected Middle Cerebral Artery (MCA) territory or an infarct that exceeds > 1/3 MCA territory