RELAXED: Recurrent Embolism Lessened by Rivaroxaban for Acute Ischemic Stroke "RELAXED"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Clinical diagnosis of acute ischemic stroke or transient ischemic attack (TIA)
- Having non-valvular atrial fibrillation
- Visiting the clinic/hospital within 48 hours of the onset of acute ischemic stroke or TIA
- Identification of an infarct in the middle cerebral artery (MCA) territory (symptoms ascribable to ischemia in the MCA territory in TIA patients)
- Initiation of treatment with rivaroxaban within 30 days of the onset of acute ischemic stroke or TIA
- Written informed consent by patients

Exclusion Criteria

- hypersensitivity to rivaroxaban 2) Active bleeding (clinically significant hemorrhage) including gastrointestinal hemorrhage
- liver disease complicated with coagulation disorder
- liver disorder corresponding to Child-Pugh Class B or C
- renal failure (creatinine clearance: <15 mL/minute)
- poorly controlled hypertension (higher than 180/100)
- Woman who are or are likely to be pregnant
- Ongoing treatment with HIV protease inhibitors including ritonavir, atazanavir and indinavir
- Ongoing treatment with itraconazole, voriconazole and ketoconazole
- Active bacterial endocarditis
- Patients considered by the investigator to be unsuitable for participating in this study