The investigators hypothesize that inflammation in carotid plaque is predictive of the extent of ischemic lesion burden on the brain and will add to risk stratification for individuals with carotid disease.
1. To investigate the relationship of carotid inflammation, as measured by FDG positron emission tomography (PET) to standardized uptake value in atherosclerotic plaque, with the number of covert brain infarcts.
2. To investigate the relationship of FDG PET standardized uptake value with the relative volume of white matter hyperintensity.
3. To correlate vascular inflammation in the entire aorta and aortoiliac vessels to carotid inflammation and cerebral infarcts and white matter disease.
Trial Stopped: difficulties recruiting this population for study population
- PET/CT imaging with F-18 fluorodeoxyglucose Radiation
Intervention Desc: Dose of 5 MBq/kg F-18-FDG given to fasting participant. Nuclear whole body imaging starting at 3 hours post-injection. The relation of the PET/CT image results and both the number of covert brain infarcts and the extent of white matter MRI hyperintensity will be investigated. ARM 1: Kind: Experimental Label: Image comparison and association ARM 2: Kind: Experimental Label: Nuclear imaging Description: PET/CT imaging with F-18 fluorodeoxyglucose
- Allocation: Non-Randomized
- Masking: Open Label
- Purpose: Screening
- Intervention: Single Group Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Plaque Inflammation||30 days||No|