The purpose of this study is to investigate whether there is an association between stroke or heart attack and reactivation of varicella zoster virus, measured by antibody levels, using linked data from the Health Survey for England and secondary care.
This study will use a case control design to investigate whether adult participants in the Health Survey for England between 2009 and 2013 who were admitted to hospital with either a stroke or heart attack had higher preceding levels of varicella zoster virus antibodies measured in stored serum samples compared to matched controls with no history of heart attack or stroke, controlling for a range of potential demographic, lifestyle and clinical confounders.
This study is funded by the University College London Hospitals Biomedical Research Centre Fast Track grant scheme and has received ethics approval (ref 15/NW/0456).
- Observation: Case Control
- Perspective: Retrospective
- Sampling: Non-Probability Sample
The study population will be drawn from adults who have already participated in the Health Survey for England between 2009 and 2013 and who have a stored serum sample available for analysis. No new participants will be recruited.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Odds ratio for the effect of high serum antibody titre on stroke or other vascular outcomes||Outcome assessed within 5 years of serum sample||No|
|Secondary||Prevalence of age- and sex-specific serum VZV antibody titres as a marker for virus reactivation||Assessed at baseline recruitment to the HSE||No|