To compare the efficacy of temporary anticoagulation with heparin to the efficacy of aspirin in preventing cerebral infarction in hospitalized patients with recent transient ischemic attacks (TIAs).
- Heparin (acute stroke) Drug
Intervention Desc: Intravenous anticoagulant.
Prospective, randomized, unblinded, pilot study of 55 patients.
Patients were randomized to receive either intravenous heparin sodium (5,000 units bolus followed by constant maintenance infusion to achieve PTT 1.5-2.0 times the baseline) or aspirin two 325-mg tablets bid). Heparin therapy was continued for a minimum of 3 days and a maximum of 9 days. Aspirin therapy was continued for a minimum of 3 days and a maximum of 15 days. Patients were treated until surgery or long-term medical therapy was instituted.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Fatal or nonfatal cerebral infarction and recurrent TIAs occurring during hospitalization.|