To assess the safety and feasibility of magnesium therapy.
- Magnesium Drug
Intervention Desc: Ion channel blocker (blocks voltage gated calcium channels and NMDA receptors)
Randomized, double-blind, placebo-controlled pilot trial involving 60 patients at a single center.
Sixty patients were randomized to magnesium sulfate (8 mmol IV over 15 minutes followed by 65 mmol over 24 hours) or placebo. Pulse, blood pressure, and serum magnesium levels were monitored.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Death or significant functional impairment (Barthel Index score <60) at 3 months.|
|Secondary||Barthel Index, Rankin Scale and NIH Stroke Scale at 5 and 90 days and 10m walking time at 3 months.|