To evaluate rapid hemodilution in the early phase of ischemic stroke by the combination of venesection (250-650 ml during the first 2 days) and administration of low-molecular weight dextran.
- Hemodilution Procedure/Surgery
Intervention Desc: Decreased viscosity may increase cerebral blood flow or oxygen delivery
- Dextran Drug
Intervention Desc: Dextran is used as a volume expander.
Prospective, controlled trial involving 102 patients at a single hospital.
52 patients were randomized to hemodilution therapy and 50 to control. Mean hemoglobin was reduced from 14.7 to 12.7 g/l, hematocrit from 43 to 37% over the first 2 days. Hemodilution was then maintained by repeated dextran infusions.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Neurological assessment by Fritz & Werner modification of the Mathew score performed prior to randomization and at days 3 and 9.|