Randomized Controlled Trial of Hemodilution Therapy in Acute Ischemic Stroke

Completed

Phase N/A Results

Trial Description

To evaluate rapid hemodilution in the early phase of ischemic stroke by the combination of venesection (250-650 ml during the first 2 days) and administration of low-molecular weight dextran.

Interventions

  • Hemodilution Procedure/Surgery
    Intervention Desc: Decreased viscosity may increase cerebral blood flow or oxygen delivery
  • Dextran Drug
    Intervention Desc: Dextran is used as a volume expander.

Trial Design

Prospective, controlled trial involving 102 patients at a single hospital.

Patient Involvement

52 patients were randomized to hemodilution therapy and 50 to control. Mean hemoglobin was reduced from 14.7 to 12.7 g/l, hematocrit from 43 to 37% over the first 2 days. Hemodilution was then maintained by repeated dextran infusions.

Outcomes

Type Measure Time Frame Safety Issue
Primary Neurological assessment by Fritz & Werner modification of the Mathew score performed prior to randomization and at days 3 and 9.