r-tPA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke Recovery "rtPA-RIC"

Not yet recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

1. Male or female with age from 45 to 80;
2. Acute ischemic stroke;
3. National Institutes of Health Stroke Scale (NIHSS) score of 5-15 and modified Rankin Scale (mRS) score of 2-5;
4. mRS score less than 1 before onset of stroke symptom;
5. Onset of stroke symptoms within 4.5h before initiation of intravenous r-tPA thrombolytic therapy;
6. Good compliance for Remote Ischemic Conditioning(RIC) therapy;
7. Informed consent obtained.

Exclusion Criteria

1. Stroke or serious head trauma within the previous 3 months
2. Major surgery or severe trauma with in the preceding 3 months
3. Intracranial hemorrhage
4. Systolic pressure greater than 185 mm Hg or diastolic pressure greater than 110 mm Hg, or aggressive treatment intravenous medication) necessary to reduce blood pressure to these limits
5. Symptoms rapidly improving
6. Symptoms suggestive of subarachnoid hemorrhage, even if CT scan was normal
7. Gastrointestinal hemorrhage or urinary tract hemorrhage within the previous 21 days
8. Arterial puncture at a noncompressible site within the previous 7 days
9. Seizure at the onset of stroke
10. Platelet count of less than 100,000 per cubic millimeter
11. Received heparin within the 48 hours preceding the onset of stroke and had an elevated partial-thromboplastin time
12. Received oral anticoagulation therapy preceding the onset of stroke and INR greater than 1.7 or prothrombin times greater than 15 seconds
13. CT showed a multiple infarction (low density area greater than 1/3 cerebral hemisphere)
14. Use or plan to use intervention for diagnosis or treating
15. Intracranial neoplasm, cerebral aneurysm or arteriovenous malformation
16. Any of the following unequivocal cardiac source of embolism: rheumatic mitral and or aortic stenosis, prosthetic heart valves, atrial fibrillation, atrial flutter, sick sinus syndrome, left atrial myxoma, patent foramen ovale, left ventricular mural thrombus or valvular vegetation, congestive heart failure, bacterial endocarditis, or any other cardiovascular condition interfering with the participation
17. severe hepatic or renal dysfunction
18. Contraindication for remote ischemic conditioning: severe soft tissue injury, fracture, or peripheral vascular disease in the upper limbs.
19. Life expectancy<1 years
20. Pregnant or breast-feeding women
21. Unwilling to be followed up or poor compliance for treatment
22. Patients being enrolled or having been enrolled in other clinical trial within 3 months prior to this clinical trial