Pushing Spatiotemporal Limits for 4D Flow MRI and Dynamic MRA in the Brain at Ultra-High Field


Phase Results N/A

Trial Description

This study aims at investigating the blood hemodynamics with high spatiotemporal resolution in patients with brain aneurysms and AVMs as well as in healthy controls. Parameters such as peak blood velocity, wall shear stress and other derived parameters will be obtained from 4D flow MRI data acquired at ultra-high field strength (7 Tesla).

Detailed Description

The hemodynamic factors responsible for hemorrhagic stroke, resulting in wide variations in the clinical management of underlying vascular lesions, especially when they are found in asymptomatic individuals or individuals with symptoms not related to the disease. Therefore, there is an urgent need for the development of reliable biomarkers based on hemodynamic parameters, which can then enable improvements in risk assessment in patients presenting with these lesions. This need can be met by non-invasive Magnetic Resonance Imaging (MRI) techniques that provide information on high resolution vascular anatomy, visualization of cerebral hemodynamics and quantitative information about blood velocity. However, such techniques as presently employed at 1.5 or 3 Tesla are limited by spatial resolution and prolonged data acquisition times.
The primary goal of this proposal is to overcome these current limitations by exploiting Ultra-High Fields (UHF, i.e. ≥ 7 Tesla (7T)) to attain significantly higher spatial resolution, faster acquisitions and increased lesion conspicuity utilizing
- Qualitative exploration of intracranial blood hemodynamics,
- Quantitative imaging of the spatiotemporally resolved blood velocity vector,
- Derivation of hemodynamic parameters.



  • 7 Tesla MRI Device
    Intervention Desc: MR imaging using a 7 Tesla MR system.
    ARM 1: Kind: Experimental
    Label: Healthy subjects
    Description: Subjects with no contraindications to magnetic resonance imaging will undergo 4D flow MRI scanning.
    ARM 2: Kind: Experimental
    Label: Patients
    Description: Patients with an unruptured brain aneurysm or an unruptured arteriovenous malformation (AVM) with no contraindications to magnetic resonance imaging will undergo 4D flow MRI scanning

Trial Design

  • Observation: Case Control
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

Patients, age 18-75 years; - Patients with previously un-ruptured AVMs, who have had a catheter-guided DSA for evaluation of the AVM; any Spetzler-Martin grade; patients with one or more un-ruptured AVMs regardless of symptoms - Patients with non-symptomatic patients; one or more un-ruptured conservatively managed aneurysms, all aneurysm sizes and shapes (fusiform, saccular, sessile). Subjects: - healthy subjects between 18 and 75 years.


Type Measure Time Frame Safety Issue
Primary Altered brain flow hemodynamics in patients with aneurysms and AVMs compared to normal subjects 2 years No
Primary Brain Flow Dynamics 2 years