Contrast-enhanced ultrasound(CEUS) of carotid artery plaque is a novel method that enabled direct visualization of neovessels in the vulnerable plaque. Plaque enhancement with CEUS showed correlation with the histologic density of neovessels within the carotid plaque and the previous cardiovascular events. Vulnerable plaques with a high risk of thromboembolic complications and rapid progression is associated with acute ischemic stroke. The prognostic value of vulnerable carotid artery plaque depicted with CEUS has not been fully investigated. The purpose of this study is to define prognostic value of plaque enhancement on carotid CEUS in acute stroke patients. Research question is; in acute ischemic stroke patients with ipsilateral carotid plaque as probable etiology of stroke, is the presence of carotid plaque enhancement on CEUS independent predictor of future stroke.
Hospitalized acute ischemic stroke patients with ipsilateral carotid artery stenosis.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Composite of recurrent stroke, vascular death and myocardial infarction||12 months|
|Secondary||Ipsilateral stroke||12 months|
|Secondary||All-cause mortality||12 months|
|Secondary||Carotid intervention||12 months|