To compare the preventive efficacy of low-intensity anticoagulation (AC), and regular-intensity AC therapies with that of aspirin for the occurrence of thromboembolism in non-rheumatic atrial fibrillation (AF) patients.
- Warfarin (Coumadin®)Drug
Intervention Desc: Anticoagulant (Vitamin K antagonist)
Randomized, primary-care based trial of 729 patients at 15 centers.
Patients eligible for regular-intensity AC were randomly assigned to aspirin at 150 mg/d, low-intensity AC, or regular AC in group I. In cases of noneligibility for regular AC, the trial randomized patients between aspirin and low-intensity AC (assigned to group II). Patients were followed by general practitioner every four months until the end of the study or earlier death.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Stroke (including intracranial hemorrhage), systemic embolism, major hemorrhage, or vascular death.|
|Secondary||Nonfatal myocardial infarction (ECG registration and laboratory findings), retinal infarct, TIA, minor bleeding complication, and death by non-vascular cause.|