To determine whether fever can be prevented by prophylactic administration of antipyretic medication during the acute phase after ischemic stroke.
- Acetaminophen (Tylenol)Drug
Other Names: Tylenol Intervention Desc: Anti-pyretic analgesic; potent inhibitor of hemoprotein-catalyzed lipid peroxidatrion with an IC50 for hemoglovin of 15uM, which is in the range of plasma levels resulting from therapeutic doses of the drug in humans. It acts by reducing the ferryl-oxo radical form of the heme, and thereby prevents formation of the hemoprotein radical that initiates lipid peroxidation.
Randomized, placebo-controlled trial of 42 patients.
Patients were randomized to either receive 1g acetaminophen (AAP) four times daily or matching placebo for 5 days. Temperature was measured with an infrared aural thermometer every 6 hrs.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Temperature of > 37.5° Celsius during the study period.|
|Secondary||Occurrence of side effects of AAP.|