Prevention of Cardiovascular Events (eg, Death From Heart or Vascular Disease, Heart Attack, or Stroke) in Patients With Prior Heart Attack Using Ticagrelor Compared to Placebo on a Background of Aspirin "PEGASUS"

Completed

Phase 3 Results

Update History

10 Dec '15
The eligibility criteria were updated.
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Inclusion Criteria: - Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction. - Females of child-bearing potential must have a negative pregnancy test at enrollment - Persons who are currently taking aspirin between 75 and 150 mg once daily Exclusion Criteria: - Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start - Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start - Persons with known bleeding disorders - Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin - Persons with a history of ischemic stroke - Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. - Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker - Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery - Persons with known severe liver disease - Persons with kidney failure requiring dialysis - Persons with life expectancy < 1 year
Old
Inclusion Criteria: - Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction. - Females of child-bearing potential must have a negative pregnancy test at enrollment - Persons who are currently taking aspirin between 75 and 150 mg once daily Exclusion Criteria: - Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start - Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start - Persons with known bleeding disorders - Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin - Persons with a history of ischemic stroke - Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. - Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker - Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery - Persons with known severe liver disease - Persons with kidney failure requiring dialysis - Persons with life expectancy < 1 year
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A location was updated in Oslo.
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A location was updated in Skien.
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A location was updated in Tromso.
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A location was updated in San Borja.
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A location was updated in Callao.
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A location was updated in Lima.
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A location was updated in Lipa City.
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A location was updated in San Juan.
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A location was updated in Cebu City.
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A location was updated in Iloilo City.
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A location was updated in Las Pinas City.
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A location was updated in Mandaluyong City.
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A location was updated in Manila.
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A location was updated in Pasig City.
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A location was updated in Quezon.
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A location was updated in Quezon City.
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A location was updated in Bialystok.
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A location was updated in Bielsko Biala.
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A location was updated in Bydgoszcz.
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A location was updated in Chorzow.
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A location was updated in Gdansk.
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A location was updated in Gdynia.
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A location was updated in Gizycko.
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A location was updated in Krakow.
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A location was updated in Lancut.
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A location was updated in Leczna.
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A location was updated in Legnica.
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A location was updated in Lodz.
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A location was updated in Lubin.
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A location was updated in Nowa Sol.
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A location was updated in Olawa.
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A location was updated in Olsztyn.
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A location was updated in Opole.
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A location was updated in Ostrow Mazowiecka.
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A location was updated in Piotrkow.
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A location was updated in Plock.
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A location was updated in Poznan.
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A location was updated in Skierniewice.
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A location was updated in Sobotka.
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A location was updated in Sokolka.
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A location was updated in Szczecin.
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A location was updated in Tarnow.
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A location was updated in Torun.
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A location was updated in Warszawa.
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A location was updated in Wloclawek.
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A location was updated in Wroclaw.
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A location was updated in Pitesti.
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A location was updated in Cluj Napoca.
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A location was updated in Bacau.
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A location was updated in Braila.
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A location was updated in Brasov.
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A location was updated in Bucharest.
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A location was updated in Bucuresti.
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A location was updated in Buzau.
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A location was updated in Craiova.
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A location was updated in Deva.
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A location was updated in Focsani.
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A location was updated in Iasi.
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A location was updated in Sibiu.
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A location was updated in Suceava.
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A location was updated in Tg. Mures.
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A location was updated in Timisoara.
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A location was updated in Moscow.
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A location was updated in Ekaterinburg.
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A location was updated in Gatchina.
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A location was updated in Kazan.
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A location was updated in Krasnodar.
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A location was updated in Moscow.
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A location was updated in Nizhnii Novgorod.
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A location was updated in Novosibirsk.
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A location was updated in Perm.
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A location was updated in Saint Petersburg.
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A location was updated in Saratov.
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A location was updated in St.Petersburg.
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A location was updated in Vladikavkaz.
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A location was updated in Volgograd.
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A location was updated in Banska Bystrica.
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A location was updated in Bardejov.
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A location was updated in Bratislava.
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A location was updated in Komarno.
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A location was updated in Kosice.
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A location was updated in Liptovsky Hradok.
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A location was updated in Liptovsky Mikulas.
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A location was updated in Martin.
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A location was updated in Nitra.
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A location was updated in Partizanske.
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A location was updated in Piestany.
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A location was updated in Povazska Bystrica.
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A location was updated in Presov.
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A location was updated in Ruzomberok.
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A location was updated in Trnava.
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A location was updated in Zilina.
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A location was updated in Gatesville.
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A location was updated in Bloemfontein.
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A location was updated in Kempron Park.
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A location was updated in Pretoria.
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A location was updated in Soweto.
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A location was updated in Durban.
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A location was updated in Panorama.
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A location was updated in Parow.
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A location was updated in Cape Town.
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A location was updated in Somerset West.
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A location was updated in Cape Town.
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A location was updated in Centurion.
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A location was updated in Durban.
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A location was updated in Johannesburg.
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A location was updated in Pretoria.
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A location was updated in Worcester.
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A location was updated in Almeria.
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A location was updated in Malaga.
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A location was updated in Sevilla.
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A location was updated in Aviles.
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A location was updated in Oviedo.
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A location was updated in Barcelona.
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A location was updated in Hospitalet de Llobregat(barcel.
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A location was updated in Sabadell.
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A location was updated in Madrid.
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A location was updated in Majadahonda.
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A location was updated in San Sebastian de Los Reyes.
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A location was updated in Valencia.
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A location was updated in Don Benito (badajoz).
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A location was updated in Palma de Mallorca.
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A location was updated in Bilbao.
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A location was updated in Eksjo.
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A location was updated in Goteborg.
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A location was updated in Jonkoping.
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A location was updated in Linkoping.
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A location was updated in Ljungby.
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A location was updated in Lund.
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A location was updated in Malmo.
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A location was updated in Molndal.
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A location was updated in Orebro.
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A location was updated in Ostersund.
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A location was updated in Stockholm.
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A location was updated in Sundsvall.
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A location was updated in Umea.
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A location was updated in Vasteras.
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A location was updated in Ankara.
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A location was updated in Adana.
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A location was updated in Ankara.
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A location was updated in Istanbul.
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A location was updated in Izmir.
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A location was updated in Malatya.
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A location was updated in Mersin.
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A location was updated in Dnepropetrovsk.
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A location was updated in Donetsk.
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A location was updated in Kharkiv.
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A location was updated in Kharkov.
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A location was updated in Kiev.
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A location was updated in Kyiv.
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A location was updated in Lviv.
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A location was updated in Uzhgorod.
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A location was updated in Vinnitsa.
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A location was updated in Zaporozye.
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A location was updated in ELY.
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A location was updated in Airdrie.
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A location was updated in Antrim.
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A location was updated in Belfast.
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A location was updated in Blackpool.
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A location was updated in Bournemouth.
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A location was updated in Bristol.
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A location was updated in Coventry.
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A location was updated in Dundee.
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A location was updated in Hastings.
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A location was updated in London.
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A location was updated in Manchester.
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A location was updated in Middlesborough.
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A location was updated in Northampton.
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A location was updated in Nottingham.
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A location was updated in Peterborough.
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A location was updated in Rotherham.
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A location was updated in Sheffield.
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A location was updated in Swansea.
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A location was updated in Torquay.
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A location was updated in York.
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7 Mar '13
A location was updated in Moncton.
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A location was updated in Kitchener.
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20 Dec '12
A location was updated in Mission.
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A location was updated in Kitchener.
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2 Oct '12
A location was updated in Bristol.
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A location was updated in Taylors.
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27 Jul '12
A location was updated in Ann Arbor.
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A location was updated in Detroit.
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A location was updated in Chicoutimi.
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19 May '12
A location was updated in Melbourne.
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A location was updated in Pittsburgh.
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7 Apr '12
A location was updated in Augusta.
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A location was updated in Evansville.
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The overall status was updated to "Recruiting" at Research Site.
A location was updated in Salisbury.
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A location was updated in Haddon Heights.
New
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A location was updated in New York.
New
The overall status was updated to "Not yet recruiting" at Research Site.
A location was updated in Charlotte.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Haedo.
New
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A location was updated in Ciudad de Buenos Aires.
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A location was updated in Mons.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Salvador.
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A location was updated in Votuporanga.
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A location was updated in Sao Paulo.
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A location was updated in Cornwall.
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A location was updated in Beijing.
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A location was updated in Hankou,wuhan.
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A location was updated in Nanjing.
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A location was updated in Shengyang.
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A location was updated in Hang Zhou.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Chongqing.
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A location was updated in Chongqing.
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A location was updated in Shanghai.
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A location was updated in Shenyang.
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A location was updated in Xi'an City.
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A location was updated in Pessac.
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A location was updated in S Maria Capua Vetere.
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A location was updated in Sessa Aurunca.
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A location was updated in Legnano.
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A location was updated in Carpi.
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A location was updated in Sagamihara.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Matsue.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in San Juan.
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A location was updated in Izmir.
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A location was updated in Izmir.
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A location was updated in Malatya.
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16 Dec '11
A location was updated in Phoenix.
New
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A location was updated in La Mesa.
New
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A location was updated in Los Angeles.
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A location was updated in Crystal River.
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A location was updated in Pannama City.
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A location was updated in St Petersburg.
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A location was updated in Peachtree Dunwoody Road.
New
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A location was updated in Bannockburn.
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A location was updated in Melrose Park.
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A location was updated in Rock Island.
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A location was updated in Fort Wayne.
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A location was updated in Iowa City.
New
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A location was updated in West Des Moines.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Crestview Hills.
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A location was updated in New Iberia.
New
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A location was updated in Oxon Hill.
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A location was updated in Bay City.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Grand Blanc.
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A location was updated in Grand Rapids.
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A location was updated in New Windsor.
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A location was updated in Stony Brook.
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A location was updated in Rocky Mount.
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A location was updated in Winston Salem.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Grand Forks.
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A location was updated in Garfield Heights.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Camp Hill.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Mine Hill.
New
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A location was updated in West Chester.
New
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A location was updated in Johnson City.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Oak Ridge.
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A location was updated in Round Rock.
New
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A location was updated in San Antonio.
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A location was updated in Ramos Mejia.
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A location was updated in San Nicolas.
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A location was updated in Cordoba.
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A location was updated in Chermside.
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A location was updated in Heidelberg.
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A location was updated in Richmond.
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A location was updated in Brussels.
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A location was updated in Gent.
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A location was updated in Turnhout.
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A location was updated in Maceio.
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A location was updated in Brasilia.
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A location was updated in Campo Grande.
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A location was updated in Campina Grande Do Sul.
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A location was updated in Blumenau.
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A location was updated in Ribeirao Preto.
New
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A location was updated in S.j.rio Preto.
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A location was updated in Sao Jose Do Rio Preto.
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A location was updated in Rio de Janeiro.
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A location was updated in Gotse Delchev.
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A location was updated in Pernik.
New
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A location was updated in Razlog.
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A location was updated in St. John's.
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A location was updated in Concepcion.
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A location was updated in Ceska Lipa.
New
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A location was updated in Marianske Lazne.
New
The overall status was removed for Research Site.
A location was updated in La Rochelle.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Le Chesnay.
New
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A location was updated in Marseille.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Paris.
New
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A location was updated in Tourcoing.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Kiel.
New
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A location was updated in Benevento.
New
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A location was updated in Brescia.
New
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A location was updated in San Remo.
New
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A location was updated in Perugia.
New
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A location was updated in Reggio Emilia.
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A location was updated in Albano Laziale.
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A location was updated in Sorrento Na.
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A location was updated in Kamogawa-shi.
New
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A location was updated in Imabari-shi.
New
The overall status was removed for Research Site.
A location was updated in Himeji-shi.
New
The overall status was removed for Research Site.
A location was updated in Sakaide-shi.
New
The overall status was removed for Research Site.
A location was updated in Saga.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Almere.
New
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A location was updated in EDE.
New
The overall status was removed for Research Site.
A location was updated in Hilversum.
New
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A location was updated in Lipa City.
New
The overall status was removed for Research Site.
A location was updated in Iloilo City.
New
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A location was updated in Las Pinas City.
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A location was updated in Mandaluyong City.
New
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A location was updated in Pasig City.
New
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A location was updated in Bielsko Biala.
New
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A location was updated in Chorzow.
New
The overall status was removed for Research Site.
A location was updated in Skierniewice.
New
The overall status was removed for Research Site.
A location was updated in Torun.
New
The overall status was removed for Research Site.
A location was updated in Wroclaw.
New
The overall status was removed for Research Site.
A location was updated in Galati.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Moscow.
New
The overall status was removed for Research Site.
A location was updated in Krasnodar.
New
The overall status was removed for Research Site.
A location was updated in Nizhnii Novgorod.
New
The overall status was removed for Research Site.
A location was updated in Vladikavkaz.
New
The overall status was removed for Research Site.
A location was updated in Durban.
New
The overall status was removed for Research Site.
A location was updated in Majadahonda.
New
The overall status was removed for Research Site.
A location was updated in San Sebastian de Los Reyes.
New
The overall status was removed for Research Site.
A location was updated in Valencia.
New
The overall status was removed for Research Site.
A location was updated in Bilbao.
New
The overall status was removed for Research Site.
A location was updated in Donetsk.
New
The overall status was removed for Research Site.
A location was updated in Vinnitsa.
New
The overall status was removed for Research Site.
A location was updated in Eastbourne.
New
The overall status was updated to "Recruiting" at Research Site.
22 Oct '11
A location was updated in Athens.
New
The overall status was removed for Research Site.
A location was updated in Auburn.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Birmingham.
New
The overall status was removed for Research Site.
A location was updated in Huntsville.
New
The overall status was removed for Research Site.
A location was updated in Mobile.
New
The overall status was removed for Research Site.
A location was updated in Gilbert.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Tucson.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Jonesboro.
New
The overall status was removed for Research Site.
A location was updated in Burbank.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Corona.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Duarte.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Glendale.
New
The overall status was removed for Research Site.
A location was updated in Lomita.
New
The overall status was removed for Research Site.
A location was updated in Ventura.
New
The overall status was removed for Research Site.
A location was updated in Aurora.
New
The overall status was removed for Research Site.
A location was updated in Littleton.
New
The overall status was removed for Research Site.
A location was updated in Bristol.
New
The overall status was removed for Research Site.
A location was updated in Hamden.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Hartford.
New
The overall status was removed for Research Site.
A location was updated in Harwinton.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Norwalk.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Southington.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Newark.
New
The overall status was removed for Research Site.
A location was updated in Seaford.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Washington.
New
The overall status was removed for Research Site.
A location was updated in Aventura.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Davie.
New
The overall status was removed for Research Site.
A location was updated in Gainesville.
New
The overall status was removed for Research Site.
A location was updated in Inverness.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Jupiter.
New
The overall status was removed for Research Site.
A location was updated in Kissimmee.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Largo.
New
The overall status was removed for Research Site.
A location was updated in Melbourne.
New
The overall status was removed for Research Site.
A location was updated in Ocala.
New
The overall status was removed for Research Site.
A location was updated in Orlando.
New
The overall status was removed for Research Site.
A location was updated in Pensacola.
New
The overall status was removed for Research Site.
A location was updated in Sunrise.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Tallahassee.
New
The overall status was removed for Research Site.
A location was updated in Tamarac.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Trinity.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Wellington.
New
The overall status was removed for Research Site.
A location was updated in Augusta.
New
The overall status was removed for Research Site.
A location was updated in Conyers.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Honolulu.
New
The overall status was removed for Research Site.
A location was updated in Boise.
New
The overall status was removed for Research Site.
A location was updated in Peoria.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Evansville.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Indianapolis.
New
The overall status was removed for Research Site.
A location was updated in Muncie.
New
The overall status was removed for Research Site.
A location was updated in Valparaiso.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Elizabethtown.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Lexington.
New
The overall status was removed for Research Site.
A location was updated in Owensboro.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Alexandria.
New
The overall status was removed for Research Site.
A location was updated in Covington.
New
The overall status was removed for Research Site.
A location was updated in Shreveport.
New
The overall status was removed for Research Site.
A location was updated in Bangor.
New
The overall status was removed for Research Site.
A location was updated in Annapolis.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Salisbury.
New
The overall status was removed for Research Site.
A location was updated in Westminster.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Burlington.
New
The overall status was removed for Research Site.
A location was updated in Benzonia.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Cadillac.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Flint.
New
The overall status was removed for Research Site.
A location was updated in Jackson.
New
The overall status was removed for Research Site.
A location was updated in Kalamazoo.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Lapeer.
New
The overall status was removed for Research Site.
A location was updated in Marquette.
New
The overall status was removed for Research Site.
A location was updated in Petoskey.
New
The overall status was removed for Research Site.
A location was updated in Pontiac.
New
The overall status was removed for Research Site.
A location was updated in Saginaw.
New
The overall status was removed for Research Site.
A location was updated in Ypsilanti.
New
The overall status was removed for Research Site.
A location was updated in Baxter.
New
The overall status was removed for Research Site.
A location was updated in Duluth.
New
The overall status was removed for Research Site.
A location was updated in Minneapolis.
New
The overall status was removed for Research Site.
A location was updated in Robbinsdale.
New
The overall status was removed for Research Site.
A location was updated in Tupelo.
New
The overall status was removed for Research Site.
A location was updated in Joplin.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Kalispell.
New
The overall status was removed for Research Site.
A location was updated in Lincoln.
New
The overall status was removed for Research Site.
A location was updated in Omaha.
New
The overall status was removed for Research Site.
A location was updated in Papillion.
New
The overall status was removed for Research Site.
A location was updated in Henderson.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Linden.
New
The overall status was removed for Research Site.
A location was updated in Ridgewood.
New
The overall status was removed for Research Site.
A location was updated in Sewell.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Albuquerque.
New
The overall status was removed for Research Site.
A location was updated in Buffalo.
New
The overall status was removed for Research Site.
A location was updated in Greenvale.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Hawthorne.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Mineola.
New
The overall status was removed for Research Site.
A location was updated in New York.
New
The overall status was updated to "Not yet recruiting" at Research Site.
A location was updated in Poughkeepsie.
New
The overall status was removed for Research Site.
A location was updated in Syracuse.
New
The overall status was removed for Research Site.
A location was updated in Westfield.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Williamsville.
New
The overall status was removed for Research Site.
A location was updated in Cary.
New
The overall status was removed for Research Site.
A location was updated in Charlotte.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Durham.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Gastonia.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Hickory.
New
The overall status was removed for Research Site.
A location was updated in Jacksonville.
New
The overall status was removed for Research Site.
A location was updated in Raleigh.
New
The overall status was removed for Research Site.
A location was updated in Statesville.
New
The overall status was removed for Research Site.
A location was updated in Wilmington.
New
The overall status was removed for Research Site.
A location was updated in Winstonsalem.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Canton.
New
The overall status was removed for Research Site.
A location was updated in Cincinnati.
New
The overall status was removed for Research Site.
A location was updated in Cleveland.
New
The overall status was removed for Research Site.
A location was updated in Elyria.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Kettering.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Mansfield.
New
The overall status was removed for Research Site.
A location was updated in Sandusky.
New
The overall status was removed for Research Site.
A location was updated in Springfield.
New
The overall status was removed for Research Site.
A location was updated in Toledo.
New
The overall status was removed for Research Site.
A location was updated in Youngstown.
New
The overall status was removed for Research Site.
A location was updated in Zanesville.
New
The overall status was removed for Research Site.
A location was updated in Tulsa.
New
The overall status was removed for Research Site.
A location was updated in Altoona.
New
The overall status was removed for Research Site.
A location was updated in Beaver.
New
The overall status was removed for Research Site.
A location was updated in Doylestown.
New
The overall status was removed for Research Site.
A location was updated in Erie.
New
The overall status was removed for Research Site.
A location was updated in Harrisburg.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Johnstown.
New
The overall status was removed for Research Site.
A location was updated in Lancaster.
New
The overall status was removed for Research Site.
A location was updated in Leetsville.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Newport.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Philadelphia.
New
The overall status was removed for Research Site.
A location was updated in Pittsburgh.
New
The overall status was removed for Research Site.
A location was updated in Sayre.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Scranton.
New
The overall status was removed for Research Site.
A location was updated in Sellersville.
New
The overall status was removed for Research Site.
A location was updated in York.
New
The overall status was removed for Research Site.
A location was updated in Providence.
New
The overall status was removed for Research Site.
A location was updated in Anderson.
New
The overall status was removed for Research Site.
A location was updated in Charleston.
New
The overall status was removed for Research Site.
A location was updated in Florence.
New
The overall status was removed for Research Site.
A location was updated in Greenville.
New
The overall status was removed for Research Site.
A location was updated in Taylors.
New
The overall status was removed for Research Site.
A location was updated in Bristol.
New
The overall status was removed for Research Site.
A location was updated in Chattanooga.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Knoxville.
New
The overall status was removed for Research Site.
A location was updated in Nashville.
New
The overall status was removed for Research Site.
A location was updated in Amarillo.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Austin.
New
The overall status was removed for Research Site.
A location was updated in Georgetown.
New
The overall status was removed for Research Site.
A location was updated in Grapevine.
New
The overall status was removed for Research Site.
A location was updated in Kingwood.
New
The overall status was removed for Research Site.
A location was updated in Plano.
New
The overall status was removed for Research Site.
A location was updated in Tomball.
New
The overall status was removed for Research Site.
A location was updated in Tyler.
New
The overall status was removed for Research Site.
A location was updated in Charlottesville.
New
The overall status was removed for Research Site.
A location was updated in Danville.
New
The overall status was removed for Research Site.
A location was updated in Lynchburg.
New
The overall status was removed for Research Site.
A location was updated in Norfolk.
New
The overall status was removed for Research Site.
A location was updated in Richmond.
New
The overall status was removed for Research Site.
A location was updated in Renton.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Tacoma.
New
The overall status was removed for Research Site.
A location was updated in Wenatchee.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Marshfield.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Milwaukee.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Wausau.
New
The overall status was removed for Research Site.
A location was updated in Caba.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Cordoba.
New
The overall status was removed for Research Site.
A location was updated in Cordoba.
New
The overall status was removed for Research Site.
A location was updated in Bruce.
New
The overall status was removed for Research Site.
A location was updated in Greenslopes.
New
The overall status was removed for Research Site.
A location was updated in Meadobank.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Launceston.
New
The overall status was removed for Research Site.
A location was updated in Brussels.
New
The overall status was removed for Research Site.
A location was updated in Charleroi.
New
The overall status was removed for Research Site.
A location was updated in Edegem.
New
The overall status was removed for Research Site.
A location was updated in Lalouviere.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Liege.
New
The overall status was removed for Research Site.
A location was updated in Goiania.
New
The overall status was removed for Research Site.
A location was updated in Uberlandia.
New
The overall status was removed for Research Site.
A location was updated in Curitiba.
New
The overall status was removed for Research Site.
A location was updated in Campinas.
New
The overall status was removed for Research Site.
A location was updated in Campinas.
New
The overall status was removed for Research Site.
A location was updated in Marilia.
New
The overall status was removed for Research Site.
A location was updated in Saopaulo.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Saopaulo.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Nanaimo.
New
The overall status was updated to "Withdrawn" at Research Site.
A location was updated in Kitchener.
New
The overall status was removed for Research Site.
A location was updated in Ottawa.
New
The overall status was removed for Research Site.
A location was updated in Saint-jerome.
New
The overall status was removed for Research Site.
A location was updated in Temuco.
New
The overall status was removed for Research Site.
A location was updated in Avignon.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Marseille.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Nimes.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Nimes.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Orleans.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Paris.
New
The overall status was removed for Research Site.
A location was updated in Paris.
New
The overall status was removed for Research Site.
A location was updated in Bari.
New
The overall status was removed for Research Site.
A location was updated in Rozzano.
New
The overall status was removed for Research Site.
A location was updated in Pisa.
New
The overall status was removed for Research Site.
A location was updated in Roma.
New
The overall status was removed for Research Site.
A location was updated in Matsuyama.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Fukui-shi.
New
The overall status was removed for Research Site.
A location was updated in Koriyama-shi.
New
The overall status was removed for Research Site.
A location was updated in Kure.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Sapporo-shi.
New
The overall status was removed for Research Site.
A location was updated in Amagasaki-shi.
New
The overall status was removed for Research Site.
A location was updated in Yokohama.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Kumamoto-shi.
New
The overall status was removed for Research Site.
A location was updated in Yatsushiro-city.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Yatsushiro-shi.
New
The overall status was removed for Research Site.
A location was updated in Kyoto-shi.
New
The overall status was removed for Research Site.
A location was updated in Matsumoto-shi.
New
The overall status was removed for Research Site.
A location was updated in Suwa-shi.
New
The overall status was removed for Research Site.
A location was updated in Daito.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Kawachinagano-shi.
New
The overall status was removed for Research Site.
A location was updated in Sakai-shi.
New
The overall status was removed for Research Site.
A location was updated in Sayama-shi.
New
The overall status was removed for Research Site.
A location was updated in Wako-shi.
New
The overall status was removed for Research Site.
A location was updated in Komatsushima-shi.
New
The overall status was removed for Research Site.
A location was updated in Akishima-shi.
New
The overall status was removed for Research Site.
A location was updated in Wakayama-shi.
New
The overall status was removed for Research Site.
A location was updated in Osaka.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Uijeongbu.
New
The overall status was removed for Research Site.
A location was updated in Beverwijk.
New
The overall status was removed for Research Site.
A location was updated in Eindhoven.
New
The overall status was removed for Research Site.
A location was updated in Heerenveen.
New
The overall status was removed for Research Site.
A location was updated in Levanger.
New
The overall status was removed for Research Site.
A location was updated in Manila.
New
The overall status was removed for Research Site.
A location was updated in Gdansk.
New
The overall status was removed for Research Site.
A location was updated in Plock.
New
The overall status was removed for Research Site.
A location was updated in Sobotka.
New
The overall status was removed for Research Site.
A location was updated in Torun.
New
The overall status was removed for Research Site.
A location was updated in Bacau.
New
The overall status was removed for Research Site.
A location was updated in Braila.
New
The overall status was removed for Research Site.
A location was updated in Brasov.
New
The overall status was removed for Research Site.
A location was updated in Focsani.
New
The overall status was removed for Research Site.
A location was updated in Ekaterinburg.
New
The overall status was removed for Research Site.
A location was updated in Gatchina.
New
The overall status was removed for Research Site.
A location was updated in Novosibirsk.
New
The overall status was removed for Research Site.
A location was updated in Perm.
New
The overall status was removed for Research Site.
A location was updated in Saratov.
New
The overall status was removed for Research Site.
A location was updated in Volgograd.
New
The overall status was removed for Research Site.
A location was updated in Trnava.
New
The overall status was removed for Research Site.
A location was updated in Pretoria.
New
The overall status was removed for Research Site.
A location was updated in Pretoria.
New
The overall status was removed for Research Site.
A location was updated in Centurion.
New
The overall status was removed for Research Site.
A location was updated in Johannesburg.
New
The overall status was removed for Research Site.
A location was updated in Sunninghill.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Malaga.
New
The overall status was removed for Research Site.
A location was updated in Sevilla.
New
The overall status was removed for Research Site.
A location was updated in Oviedo.
New
The overall status was removed for Research Site.
A location was updated in Madrid.
New
The overall status was updated to "Recruiting" at Research Site.
A location was updated in Malmo.
New
The overall status was removed for Research Site.
A location was updated in Malmo.
New
The overall status was removed for Research Site.
A location was updated in Ankara.
New
The overall status was removed for Research Site.
A location was updated in Adana.
New
The overall status was removed for Research Site.
A location was updated in Istanbul.
New
The overall status was removed for Research Site.
A location was updated in Izmir.
New
The overall status was removed for Research Site.
A location was updated in Mersin.
New
The overall status was removed for Research Site.
A location was updated in Lviv.
New
The overall status was removed for Research Site.
A location was updated in London.
New
The overall status was removed for Research Site.
6 Oct '11
The eligibility criteria were updated.
New
Inclusion Criteria: - Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ≥ 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction. - Females of child-bearing potential must have a negative pregnancy test at enrollment - Persons who are currently taking aspirin between 75 and 150 mg once daily Exclusion Criteria: - Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start - Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start - Persons with known bleeding disorders - Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin - Persons with a history of ischemic stroke - Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. - Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker - Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery - Persons with known severe liver disease - Persons with kidney failure requiring dialysis - Persons with life expectancy < 1 year
Old
Inclusion Criteria: - Person who had a heart attack within 1 - 3 years ago and at least one additional risk factor: Age ? 65 years old, Diabetes requiring medication, Documented history of 2nd prior MI (>1 year ago). Angiographic evidence of multivessel CAD, and / or Chronic, non-end stage renal dysfunction. - Females of child-bearing potential must have a negative pregnancy test at enrollment - Persons who are currently taking aspirin between 75 and 150 mg once daily Exclusion Criteria: - Persons who are being treated with agents inhibiting blood clotting if the agent cannot be stopped at study start - Persons who have planned coronary, cerebrovascular, or peripheral arterial Revascularization (invasive surgery) at study start - Persons with known bleeding disorders - Persons who need chronic oral anticoagulant therapy or chronic low-molecular-weight heparin - Persons with a history of ischemic stroke - Persons with a history of intracranial bleeding at any time, a tumor or blood vessel abnormality in the brain and/or spinal cord at any time, a history of surgery involving the brain or spinal cord within the last 5 years, or a history of bleeding from the gastrointestinal tract (eg, esophagus, stomach, colon, rectum) within the last 6 months or a major surgery within the last 30 days. - Persons considered to be at risk of bradycardic events unless already treated with a permanent pacemaker - Persons who have had open heart surgery within the past 5 years, unless the person had a heart attack after the surgery - Persons with known severe liver disease - Persons with kidney failure requiring dialysis - Persons with life expectancy < 1 year