Prevalence of Trephined Syndrome After Decompressive Craniectomy "TS"


Phase N/A Results N/A



  • Akins PT, Guppy KH. Sinking skin flaps, paradoxical herniation, and external brain tamponade: a review of decompressive craniectomy management. Neurocrit Care. 2008;9(2):269-76. Review. Pubmed ID:18064408
  • Beauchamp KM, Kashuk J, Moore EE, Bolles G, Rabb C, Seinfeld J, Szentirmai O, Sauaia A. Cranioplasty after postinjury decompressive craniectomy: is timing of the essence? J Trauma. 2010 Aug;69(2):270-4. doi: 10.1097/TA.0b013e3181e491c2. Pubmed ID:20699735
  • Bijlenga P, Zumofen D, Yilmaz H, Creisson E, de Tribolet N. Orthostatic mesodiencephalic dysfunction after decompressive craniectomy. J Neurol Neurosurg Psychiatry. 2007 Apr;78(4):430-3. Epub 2006 Nov 21. Pubmed ID:17119005
  • Chang V, Hartzfeld P, Langlois M, Mahmood A, Seyfried D. Outcomes of cranial repair after craniectomy. J Neurosurg. 2010 May;112(5):1120-4. doi: 10.3171/2009.6.JNS09133. Pubmed ID:19612971
  • Dujovny M, Agner C, Aviles A. Syndrome of the trephined: theory and facts. Crit Rev Neurosurg. 1999 Sep 24;9(5):271-278. Pubmed ID:10525845
  • Fodstad H, Love JA, Ekstedt J, Fridén H, Liliequist B. Effect of cranioplasty on cerebrospinal fluid hydrodynamics in patients with the syndrome of the trephined. Acta Neurochir (Wien). 1984;70(1-2):21-30. Pubmed ID:6741628
  • Honeybul S. Complications of decompressive craniectomy for head injury. J Clin Neurosci. 2010 Apr;17(4):430-5. doi: 10.1016/j.jocn.2009.09.007. Epub 2010 Feb 23. Pubmed ID:20181482
  • Joseph V, Reilly P. Syndrome of the trephined. J Neurosurg. 2009 Oct;111(4):650-2. doi: 10.3171/2009.3.JNS0984. Pubmed ID:19361266
  • Kemmling A, Duning T, Lemcke L, Niederstadt T, Minnerup J, Wersching H, Marziniak M. Case report of MR perfusion imaging in sinking skin flap syndrome: growing evidence for hemodynamic impairment. BMC Neurol. 2010 Sep 11;10:80. doi: 10.1186/1471-2377-10-80. Pubmed ID:20831824
  • Mokri B. Orthostatic headaches in the syndrome of the trephined: resolution following cranioplasty. Headache. 2010 Jul;50(7):1206-11. doi: 10.1111/j.1526-4610.2010.01715.x. Epub 2010 Jun 18. Pubmed ID:20561067
  • Ng D, Dan NG. Cranioplasty and the syndrome of the trephined. J Clin Neurosci. 1997 Jul;4(3):346-8. Pubmed ID:18638981
  • Sarov M, Guichard JP, Chibarro S, Guettard E, Godin O, Yelnik A, George B, Bousser MG, Vahedi K; DECIMAL investigators. Sinking skin flap syndrome and paradoxical herniation after hemicraniectomy for malignant hemispheric infarction. Stroke. 2010 Mar;41(3):560-2. doi: 10.1161/STROKEAHA.109.568543. Epub 2010 Jan 7. Pubmed ID:20056926
  • Schiffer J, Gur R, Nisim U, Pollak L. Symptomatic patients after craniectomy. Surg Neurol. 1997 Mar;47(3):231-7. Review. Pubmed ID:9068692
  • Stiver SI. Complications of decompressive craniectomy for traumatic brain injury. Neurosurg Focus. 2009 Jun;26(6):E7. doi: 10.3171/2009.4.FOCUS0965. Review. Pubmed ID:19485720
  • Stiver SI, Wintermark M, Manley GT. Reversible monoparesis following decompressive hemicraniectomy for traumatic brain injury. J Neurosurg. 2008 Aug;109(2):245-54. doi: 10.3171/JNS/2008/109/8/0245. Pubmed ID:18671636
  • Thavarajah D, De Lacy P, Hussien A, Sugar A. The minimum time for cranioplasty insertion from craniectomy is six months to reduce risk of infection--a case series of 82 patients. Br J Neurosurg. 2012 Feb;26(1):78-80. doi: 10.3109/02688697.2011.603850. Epub 2011 Oct 5. Pubmed ID:21973063
  • Yadla S, Campbell PG, Chitale R, Maltenfort MG, Jabbour P, Sharan AD. Effect of early surgery, material, and method of flap preservation on cranioplasty infections: a systematic review. Neurosurgery. 2011 Apr;68(4):1124-9; discussion 1130. doi: 10.1227/NEU.0b013e31820a5470. Review. Pubmed ID:21242830
  • Yang XF, Wen L, Shen F, Li G, Lou R, Liu WG, Zhan RY. Surgical complications secondary to decompressive craniectomy in patients with a head injury: a series of 108 consecutive cases. Acta Neurochir (Wien). 2008 Dec;150(12):1241-7; discussion 1248. doi: 10.1007/s00701-008-0145-9. Epub 2008 Nov 13. Pubmed ID:19005615

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