Premotor Cortex: A New Target for Stroke Motor Rehabilitation

Recruiting

Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

Motor training only (pilot participants):
- Have the ability to give informed, written consent
- Be aged 18-80 years old
- Be right-handed using the Edinburgh handedness inventory
- Have intact cognitive abilities (score higher than 75th percentile on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS))
- No current depression (score less than 7 on the Hamilton Depression Rating Scale (HDRS))
- No neurological disease
- No contradictions to Transcranial Magnetic Stimulation (TMS)
- TMS over the extensor carpi ulnaris (ECU) hotspot must evoke a motor evoked potential (MEP) in the ECU muscle
- MEP amplitude must increase by at least 20% as the TMS intensity increases
- The subjects must be comfortable when receiving TMS of all strengths.
Remaining study participants:
- Have the ability to give informed, written consent
- Be aged 55-80 years old
- Be right-handed using the Edinburgh handedness inventory
- Have intact cognitive abilities (score higher than 75th percentile on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS))
- No current depression (score less than a 7 on the Hamilton Depression Rating Scale (HDRS))
- No neurological disease
- No contradictions to Transcranial Magnetic Stimulation (TMS)
- TMS over the extensor carpi ulnaris (ECU) hotspot must be able to evoke a motor evoked potential (MEP) in the ECU muscle
- MEP amplitude must increase by at least 20% as the TMS intensity increases
- The subjects must be comfortable when receiving TMS of all strengths.

Exclusion Criteria

- Impaired cognitive abilities (score lesser than 75th percentile on the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS))
- Current depression (score more than 7 on the Hamilton Depression Rating Scale (HDRS))
- Neurological disease
- Has a contradiction to TMS
- MEP cannot be evoked with TMS in the ECU muscle
- Inability to tolerate one or more TMS strengths