Prediction of Stroke-associated Pneumonia "PREDICT"

Completed

Phase N/A Results N/A

Update History

7 Feb '18
The Summary of Purpose was updated.
New
Stroke-associated pneumonia (SAP) constitutes a clinically relevant complication of stroke, because it increases the mortality and has a negative impact on the neurological prognosis of the patient. An early identification of patients at risk for SAP allowing an early initiation of antiinfective therapy may improve the prognosis. To date, no reliable prediction models or clinical scores for stroke-associated pneumonia exist. Recently, it was shown that parameters indicating an impaired immune function are associated with the subsequent occurrence of SAP and could therefore be used as predictors for SAP. This study will develop and prospectively validate a prognostic score to predict SAP based on clinical parameters. Furthermore, the study examines the prognostic properties of selected immune and infectious parameters for the prediction and diagnosis of SAP. The study will further address the question whether these infectious and immune parameters predict the 3-month-outcome. In a subgroup of patients, MRI parameters on stroke size and localization will be assessed to investigate whether these parameters might allow prediction of SAP or the 3-month-outcome.
Old
Stroke-associated pneumonia (SAP) constitutes a clinically relevant complication of stroke, because it increases the mortality and has a negative impact on the neurological prognosis of the patient. An early identification of patients at risk for SAP allowing an early initiation of antiinfective therapy may improve the prognosis. To date, no reliable prediction models or clinical scores for stroke-associated pneumonia exist. Recently, it was shown that parameters indicating an impaired immune function are associated with the subsequent occurrence of SAP and could therefore be used as predictors for SAP. This study will develop and prospectively validate a prognostic score to predict SAP based on clinical parameters. Furthermore, the study examines the prognostic properties of selected immune and infectious parameters for the prediction and diagnosis of SAP. The study will further address the question whether these infectious and immune parameters predict the 3-month-outcome. In a subgroup of patients, MRI parameters on stroke size and localization will be assessed to investigate whether these parameters might allow prediction of SAP or the 3-month-outcome.
3 Jul '17
The gender criteria for eligibility was updated to "All."
13 Feb '13
A location was updated in Berlin.
New
The overall status was removed for Charite University (Center for Stroke Research Berlin CSB & NeuroCure Clinical Research Center NCRC).
6 Oct '11
The eligibility criteria were updated.
New
Inclusion Criteria: - ischemic stroke in the anterior (ACA, MCA) and posterior cerebral circulation (PCA, BA) of any severity - stroke onset within the last 36h - age ≥ 18 - consent by the patient or the legal representative Exclusion Criteria: - intracranial hemorrhage - signs of infection at admission (clinical / paraclinical) - pre-existing dysphagia - mechanical ventilation at admission - participation in an interventional trial
Old
Inclusion Criteria: - ischemic stroke in the anterior (ACA, MCA) and posterior cerebral circulation (PCA, BA) of any severity - stroke onset within the last 36h - age ? 18 - consent by the patient or the legal representative Exclusion Criteria: - intracranial hemorrhage - signs of infection at admission (clinical / paraclinical) - pre-existing dysphagia - mechanical ventilation at admission - participation in an interventional trial