Prediction and Detection of Occult Atrial Fibrillation in Patients After Acute Cryptogenic Stroke and TIA "PROACTIA"

Recruiting

Phase N/A Results N/A

Trial Description

PROACTIA is a prospective, event-driven observational study. It aims to propose a composite scoring system in order to evaluate the risk of paroxysmal atrial fibrillation (PAF) in patients after acute cryptogenic stroke and transient ischemic attack (TIA).

Detailed Description

It will be enrolled 250 participants of both sexes within two weeks after diagnosed cryptogenic stroke and/or TIA at Akershus University Hospital, Oslo area, Norway.
Evaluation of participants' comorbidity with CHADS2-VASc score, ECG, Holter ECG, echocardiography, detection of biochemical cardiac markers and screening for obstructive sleep apnea syndrome will be performed. All participants will be monitored with a continuous cardiac rhythm during one year by implantation of implantable cardiac rhythm monitors (ICRM). All patients without high bleeding risk will get prescribed oral anticoagulants (OAC) after detection of PAF.
A biobank will be established in order to store the sampled biological material.

Conditions

Interventions

  • Implantation of ICRM Device
    Intervention Desc: All patients will be implanted with ICRM in order to detect an occult PAF.
    ARM 1: Kind: Experimental
    Label: Patients with cryptogenic stroke and TIA
    Description: Implantation of ICRM in all participants.

Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

250 participants of both sexes included at Akershus University Hospital, Norway, within two weeks after diagnosed with cryptogenic stroke and/or TIA.

Outcomes

Type Measure Time Frame Safety Issue
Primary Detection of paroxysmal atrial fibrillation One year Yes

Biospecimen Retention:Samples With DNA - Blood samples

Sponsors