Inclusion Criteria- All patients treated by iv tPA for cerebral ischaemia in routine practice in participating centres
Exclusion Criteria- index ischaemic stroke sparing MCA territory;
- thrombolytic therapy administered intra-arterially or combined with thrombectomy
- pre-stroke mRS of 2 or more
- impossibility to perform an IQCODE for any reason (no reliable informant available within 48 hours, not fluent in French or in Japanese or in a language spoken by the investigator), except when the patient had been diagnosed as demented by a specialist used to diagnose dementia (e.g. neurologist, psychiatrist, geriatrician) before stroke, or has a MMSE score of 30 at discharge.