Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.
The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.
- Observation: Case Control
- Perspective: Prospective
- Sampling: Non-Probability Sample
Adult patients with acute ischemic stroke in MCA/AchA territory within 48 hours of onset
|Type||Measure||Time Frame||Safety Issue|
|Primary||occurence of depression (GDS, SKID)||90 days||No|
|Secondary||change in salivia cortisol||90days||No|
|Secondary||change in serumcholine||90days||No|
Biospecimen Retention:Samples With DNA - Blood