Post Stroke Psychological Distress "POSTPSYDIS"


Phase N/A Results N/A

Trial Description

Neuro-psychological, cognitive and biochemical assessment matched with MR-Imaging in acute and chronic poststroke conditions.

Detailed Description

The study design relates to affective symptomatology, particularly poststroke depression and posttraumatic stress symptoms as well as to cognitive decline due to stress-related hypercortisolemia in the early phase after stroke. Extended MRI studies including a functional connectivity (fc-MRI) paradigm have been incorporated to study on subacute midbrain neurodegeneration as a possible morphological correlate of functional and clinical findings.


Trial Design

  • Observation: Case Control
  • Perspective: Prospective
  • Sampling: Non-Probability Sample

Trial Population

Adult patients with acute ischemic stroke in MCA/AchA territory within 48 hours of onset


Type Measure Time Frame Safety Issue
Primary occurence of depression (GDS, SKID) 90 days No
Secondary change in salivia cortisol 90days No
Secondary change in serumcholine 90days No

Biospecimen Retention:Samples With DNA - Blood