Post Stroke Motor Learning

Recruiting

Phase N/A Results N/A

Trial Description

Noninvasive brain stimulations (NIBS) will be used in chronic stroke patients to improve motor learning.
Functional magnetic resonance imaging will be used to evaluate the mechanisms underlying motor learning in healthy volunteers and in chronic stroke patients.

Detailed Description

transcranial direct current stimulation will be used for NIBS

Conditions

Interventions

  • Transcranial direct current stimulation tDCS Device
    Intervention Desc: tdcs (ELDITH, Neuroconn, Ilmenau, Germany)
    ARM 1: Kind: Experimental
    Label: Real
    Description: Real tDCS
    ARM 2: Kind: Experimental
    Label: sham
    Description: Sham tDCS
  • Transcranial magnetic stimulation TMS Device
    Intervention Desc: TMS (The Magstim Company Ltd, UK) Magstim 200² with a figure-of-eight coil was used to determine the hot spot eliciting consistent movements in the contralateral hand
    ARM 1: Kind: Experimental
    Label: Real
    Description: Real tDCS
    ARM 2: Kind: Experimental
    Label: sham
    Description: Sham tDCS

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Crossover Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Motor learning improvment with tDCS start of the actual session 5min before tDCS, during tDCS(each 30 secondes of the intervention), just at the end of the tDCS, after 30 min of tDCS, after 60 min of tDCS, Recall test at 1,2,3,4 weeks after the day of intervention No
Secondary neuroimaging before motor learning, during motor learning and after (immediately, 30,60min) motor learning (with or without tDCS) No
Secondary neurophysiological outcome measure start of session 5min before motor learning, just at the end of the motor learning, after 30 min of motor learning, after 60 min of motor learning, Recall test at 1,2,3,4 weeks after the day of intervention (with or without tDCS) No
Primary Motor learning improvement with tDCS Improvement on motor learning were recorded from baseline to 4 weeks after the intervention No

Sponsors