Pilot Investigation of Stem Cells in Stroke "PISCES"

Active, not recruiting

Phase 1 Results N/A

Eligibility Criteria

Inclusion Criteria

- Males
- 60 years or over
- Unilateral ischemic stroke involving subcortical white matter or Basal Ganglia 6 months to 5 years before entry
- NIHSS score minimum 6 with hemiparesis (2 or more for motor arm and leg)
- Neurologically stable for 2 m
- modified Rankin score of 2-4
- Fit for general anesthesia, neurosurgery
- Capacity to consent
- Infarct at least 1cm diameter

Exclusion Criteria

- Structural brain vascular lesions requiring surgery or increasing the risk of stereotaxic implantation
- Unstable medical conditions with expected survival <12 months
- Any medical condition that would impair participation (eg progressive neurological disorders, mental illness)
- Major surgery within 30 days
- Previous allogeneic tissue transplant
- MMSE < 24
- Epilepsy
- Coagulation disorders or anticoagulant treatment that cannot be interrupted
- Stimulants, botox, tamoxifen
- Contraindications to MRI