Persantine Aspirin Trial

Completed

Phase N/A Results

Trial Description

To test the relative efficacies of aspirin and dipyridamole in the reduction of cerebral and retinal infarction or death in patients with a history of TIA.

Interventions

Trial Design

Double-blind, randomized, cooperative trial of 890 patients at 15 centers in the U.S. and Canada.

Patient Involvement

Patients were randomized to receive either aspirin (325 mg) plus placebo four times daily or aspirin (325 mg) plus dipyridamole (75 mg) four times daily. The decision to continue or discontinue the study medications was left to the attending physician. Follow-up visits were scheduled to take place every three months beginning one month after randomization. Median total follow-up time was 25 months.

Outcomes

Type Measure Time Frame Safety Issue
Primary Stroke, retinal infarction, or death from any cause.
Secondary Subgroup analyses, deaths, adverse events.

Sponsors

Boehringer-Ingelheim