Perfusion-CT guided intravenous thrombolysis at 3 to 6 hours: feasibility and safety study


Phase N/A Results N/A

Summary of Purpose

To determine the feasibility and safety of using a newly developed perfusion-CT-software to select patients with a favorable penumbra/core-ratio for intravenous thrombolysis in the 3 to 6 hour window after onset of acute ischemic stroke.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 2 April 2009.

Unavailable Unavailable Unavailable Unavailable Unavailable Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Basics


Trial Design

To be included, the patients need to have a minimal penumbra size for a given core (infarct) size on the perfusion-CT, according to a progressive linear cut-off table. The cut-off values were selected for maximal potential benefit: the smaller the core size is (and thus the smaller the theoretical bleeding risk), the smaller the penumbra must be to for inclusion. The maximal upper size for inclusion is a core of 30% of the MCA territory (where penumbra must be at least 60%). The trial will be stopped after 4 symptomatic hemorrhages or after 12 patients are enrolled.


Not available