To assess the efficacy and safety of pentoxifylline.
- Pentoxifylline (Trental®)Drug
Intervention Desc: Vasodilator. In addition, may reduce viscosity or improve erythrocyte flexibility.
Double-blind, randomized, placebo-controlled trial involving 297 patients at 13 centers.
Study medication was administered intravenously continuously (16 mg/kg/day, maximum 1200 mg/day) for 3 days and per os (400 mg tid.) for the remainder of 28 days.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Mortality, neurologic deficits as measured by a weighted scale daily for days 1-4 and days 7, 14, and 21 and at the end of the study, and functional deficits as measured by the Barthel Index at days 7, 14, 21, and 28.|