Pentoxifylline in Acute Nonhemorrhagic Stroke

Completed

Phase 2 Results

Trial Description

To assess the efficacy and safety of pentoxifylline.

Interventions

  • Pentoxifylline (TrentalĀ®)Drug
    Intervention Desc: Vasodilator. In addition, may reduce viscosity or improve erythrocyte flexibility.

Trial Design

Double-blind, randomized, placebo-controlled trial involving 297 patients at 13 centers.

Patient Involvement

Study medication was administered intravenously continuously (16 mg/kg/day, maximum 1200 mg/day) for 3 days and per os (400 mg tid.) for the remainder of 28 days.

Outcomes

Type Measure Time Frame Safety Issue
Primary Mortality, neurologic deficits as measured by a weighted scale daily for days 1-4 and days 7, 14, and 21 and at the end of the study, and functional deficits as measured by the Barthel Index at days 7, 14, 21, and 28.