Patent Foramen Ovale in Cryptogenic Stroke Study "PICSS"


Phase 4 Results

Summary of Purpose

The study sought to assess the rate of recurrent stroke and death in stroke patients with a patent foramen ovale randomized to treatment with warfarin or aspirin. This was a multicenter study conducted at 48 U.S. Institutions.

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Trial Milestones

The following dates are available for this trial. Trial information last updated on 14 September 2011.

1 Jun 1993 11 Jun 2008 1 Jun 2000 1 Jun 2000 1 Sep 2011 Unavailable
Start Date First Received 1st Completion Completion Verification Results

Trial Design

  • Allocation: Randomized
  • Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor)
  • Purpose: Prevention
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment


  • Lynette De Los Santos Columbia University College of Physicians and Surgeons 630 W. 168th St. New York, NY 19932