Paraorbital-Occipital Alternating Current Stimulation Therapy of Patients With Post-Chiasmatic Lesions

Active, not recruiting

Phase 2/3 Results N/A

Update History

4 Dec '13
The Summary of Purpose was updated.
New
Visual field areas, which are not absolutely blind, are hypothesized to have some residual capacities that constitute their potential for vision restoration. Vision restoration can be achieved by varies methods including behavioral training and electrical brain stimulation such as transcranial direct current stimulation (tDCS) and repetitive transorbital alternating current stimulation (rtACS) which are able to influence the excitability and activity of cortical areas. It is hypothesized that transorbital alternating current stimulation (tACS) can improve the residual field of vision in patients with post-chiasmatic lesions.
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Aim is to validate that non-invasive brain stimulation can increase cortical excitability in the visual system. The investigators hypothesize that the transcranial alternating current stimulation (tACS) can improve the residual field of vision on patients with post-chiasmatic lesions.
The eligibility criteria were updated.
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Inclusion Criteria: - lesion of the tractus opticus or of the visual cortex - lesion age > 6 months - stable visual field defect with residual vision Exclusion Criteria: - electric or electronic implants, e.g. heart pacer - any metal artefacts in the head - Epilepsy - Auto-immune diseases in acute stage - mental diseases, e.g. schizophrenia etc. - diabetic retinopathy - addictive diseases - blood pressure above 160/100 mmHg - instable or high level of intraocular pressure above 27 mmHg - retinitis pigmentosa - pathological nystagmus - presence of an un-operated tumor or tumor relapse (patients with non-progressive tumor are eligible if study participation is recommended by medical authorities) - focal findings in EEG or photosensitivity (patients with single seizure more than 10 yrs ago may participate) - recurrent transitional ischemic attacks after stroke - arteriosclerosis of large blood vessels with stenosis >75% - severe coronary heart disease (CHD) - unstable angina pectoris - diabetes with blood glucose level > 9 mmol/l - myocard infarct/ cardiomyopathy - ventricular fibrillation - risk of vascular thrombosis - pregnant or breast-feeding women
Old
Inclusion Criteria: - lesion of the tractus opticus or of the visual cortex - lesion age > 6 months - stable visual field defect with residual vision Exclusion Criteria: - electric or electronic implants, e.g. heart pacer - any metal artefacts in head and truncus - Epilepsy - Auto-immune diseases in acute stage - mental diseases, e.g. schizophrenia etc. - diabetes causing diabetic retinopathy - addiction - high blood pressure (max. 160/100 mmHg) - instable or high level of intraocular pressure (>27 mmHg) - retinitis pigmentosa - pathological nystagmus - presence if an un-operated tumor or tumor relapse anywhere in the body - focal findings in EEG or photosensitivity - recurrent transitional ischemic attacks after stroke - atherosclerosis of large blood vessels with stenosis >75% - severe coronary heart disease (CHD) - unstable angina pectoris - diabetes with blood glucose level > 9 mmol/l - myocard infarct with high risk of cardio-emboly - cardiomyopathy - ventricular fibrillation - risk of vascular thrombosis - pregnant or breast-feeding women
20 Feb '13
A location was updated in Magdeburg.
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The overall status was removed for Inst. f. Medizinische Psychologie, Universitätsklinikum Magdeburg.