Optimizing Current and Electrode Montage for Transcranial Direct Current Stimulation in Stroke Patients "COBRE_JIpro3"

Recruiting

Phase 1 Results N/A

Trial Description

The purpose of this study is to determine the optimal transcranial direct current stimulation (tDCS) amplitude and electrode montage that is both safe and efficacious

Detailed Description

Transcranial direct current stimulation (tDCS) is a non-invasive brain stimulation technique that can modulate cortical excitability of targeted brain regions. Various studies have investigated tDCS use in stroke patients with motor impairments (cumulatively about 200 cases). Although these studies are mostly "proof of concept" with small sample size, they do suggest that tDCS may improve motor function. However these two questions have not been addressed systematically:
1. What is the optimal current for stroke patients?
2. What is the optimal tDCS electrode montage for stimulation?
This proposal lays the scientific foundation for systematic application of tDCS in stroke recovery research by progressively increasing tDCS currents and montages that are both safe and efficacious in population with stroke.

Conditions

Interventions

  • Transcranial direct current stimulation Device
    Other Names: tDCS
    Intervention Desc: brain stimulation using progressively increasing amounts of direct currents and in a variety of electrode montages
    ARM 1: Kind: Experimental
    Label: tDCS Application
    Description: transcranial direct current stimulation. tDCS currents are applied in increasing strengths and then in different electrode montages.

Trial Design

  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Safety/Efficacy Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary major response Immediately after intervention on the day of tDCS application No
Secondary TMS response Immediately after intervention on the day of tDCS No

Sponsors