Optimal Anticoagulation for Higher Risk Patients Post-Catheter Ablation for Atrial Fibrillation Trial "OCEAN"


Phase 4 Results N/A

Eligibility Criteria

Inclusion Criteria

1. At least one year post-successful catheter ablation for AF or left atrial flutter/tachycardia without evidence of any clinically apparent arrhythmia recurrence based on at least one 24 hour Holter and ECG within 6 months after the last ablation procedure and at least one 24 hour Holter and ECG between 6 and 12 months post-ablation or beyond.
2. Patient must have no atrial fibrillation, atrial flutter or atrial tachycardia > 30 seconds detected on a minimum 48 hour Holter monitor within two months prior to enrollment.
3. CHA2DS2-VASc risk score of 1 or more excluding patients in whom female sex or vascular disease are their sole risk factor.
4. Patients must be > 18 years of age.
Exclusion Criteria
1. does not meet all of the above listed inclusion criteria.
2. unable or unwilling to provide informed consent.
3. included in another clinical trial
4. GFR < 30 mL/min
5. contraindication to oral anticoagulation (OAC)
6. contraindication to magnetic resonance imaging (MRI)
7. metallic prosthetic heart valve
8. non-arrhythmic condition necessitating long-term OAC
9. stroke within one year prior to enrolment