Norwegian COgnitive Impairment After STroke (NorCOAST) Study "Nor-Coast"


Phase Results N/A

Trial Description

A prospective observational multicenter study aiming to describe incidence, and identify predictors for development of poststroke dementia (PSD) and mild cognitive impairment (MCI) after stroke

Detailed Description

About 15000 Norwegians suffer a stroke every year and 2/3 will be more or less disabled. In addition to motor impairments and comorbidities, disability after stroke is often related to post stroke dementia (PSD) or mild neurocognitive disorder (NCD). However, these problems are hardly addressed in stroke or dementia research and frequently ignored in clinical practise. In the Nor-COAST study an interdisciplinary research group will collaborate to establish a research platform across all Norwegian Health Authorities. The overall aim of the study is to improve competence on PSD and NCD in order to improve individual health outcomes following a stroke. The specific objectives are to determine the incidence of PSD and NCD and the consequences on function and use of health care services and to enhance the early detection of PSD and NCD by identifying a set of risk factors, ranging from genetics to physical activity. The incidence and impact of PSD and NCD on function and use of health care services, medication and life-style changes are important when planning future health care services. Tools identifying patients at risk might improve diagnostic work up and together with knowledge on pathogenic aspects it will contribute to future treatment and prevention of PSD and NCD.


Trial Design

  • Observation: Cohort
  • Perspective: Prospective
  • Sampling: Probability Sample

Trial Population

Patients with acute stroke


Type Measure Time Frame Safety Issue
Primary Score on the Montreal cognitive assessment (MOCA) 18 months No
Secondary Time spent in upright position 3 months No
Secondary Brain Imaging 18 months No
Secondary Score on Short Physical Performance Battery (sppb) 3 months No
Secondary Selfreported habits concerning smoking, alcohol, diet and medication using standardised questionnaires 3 months No

Biospecimen Retention:Samples With DNA - blood samples