To test the potential benefit of endarterectomy in patients with moderate or severe stenosis.
- Endarterectomy, carotid (CEA)Procedure/Surgery
Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.
Multi-center, randomized, controlled trial of 2226 patients at 106 centers.
Patients were divided into two predetermined categories based on the severity of carotid stenosis: 30-69% and 70-99%. Patients were then randomly assigned to receive carotid endarterectomy or medical care alone. All patients received optimal medical care, including antiplatelet therapy.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Fatal or nonfatal stroke ipsilateral to the stenosis for which the patient underwent randomization. Assessment was made at 1, 3, 6, 9, and 12 months and every 4 months thereafter.|
|Secondary||All strokes and deaths.|