North American Symptomatic Carotid Endarterectomy Trial "NASCET"

Completed

Phase 3 Results

Trial Description

To test the potential benefit of endarterectomy in patients with moderate or severe stenosis.

Interventions

  • Endarterectomy, carotid (CEA)Procedure/Surgery
    Intervention Desc: Surgical therapy to remove atherosclerotic plaque in narrowed carotid arteries.

Trial Design

Multi-center, randomized, controlled trial of 2226 patients at 106 centers.

Patient Involvement

Patients were divided into two predetermined categories based on the severity of carotid stenosis: 30-69% and 70-99%. Patients were then randomly assigned to receive carotid endarterectomy or medical care alone. All patients received optimal medical care, including antiplatelet therapy.

Outcomes

Type Measure Time Frame Safety Issue
Primary Fatal or nonfatal stroke ipsilateral to the stenosis for which the patient underwent randomization. Assessment was made at 1, 3, 6, 9, and 12 months and every 4 months thereafter.
Secondary All strokes and deaths.

Sponsors

National Institute for Neurological Disorders and Stroke, NIH