To study the safety and efficacy of round-the-clock acetaminophen administration to prevent hyperthermia in acute ischemic stroke patients.
- Hypothermia Device
Intervention Desc: Reduction of brain temperature and body temperature for neuroprotection
- Acetaminophen (Tylenol)Drug
Other Names: Tylenol Intervention Desc: Anti-pyretic analgesic; potent inhibitor of hemoprotein-catalyzed lipid peroxidatrion with an IC50 for hemoglovin of 15uM, which is in the range of plasma levels resulting from therapeutic doses of the drug in humans. It acts by reducing the ferryl-oxo radical form of the heme, and thereby prevents formation of the hemoprotein radical that initiates lipid peroxidation.
Pilot clinical trial of 16 patients.
Patients were given acetaminophen (650 mg q 4 hrs) for 72 hrs or until discharge. Cooling blankets were ordered for T>37.6 C.
|Type||Measure||Time Frame||Safety Issue|
|Primary||Oral temperatures recorded q 4 hrs.|