Non-invasive Repetitive Paraorbital Alternating Current Stimulation Therapy for Aphasia

Terminated

Phase 3 Results N/A

Eligibility Criteria

Inclusion Criteria

- stroke
- lesion age at least 6 months
- aphasia with at least moderate severity according to Aachener Aphasia Test (AAT)
- age between 40 and 75
- German-speaking (at a native speaking level)

Exclusion Criteria

- cognitive or speech-language therapy during the 2-weeks stimulation course
- intensive language training when exceeding 1 hour, 2 times a week during the 2-weeks stimulation course and the follow-up period (60 days after stimulation was completed)
- additional neurological diseases, e.g. surgical brain tumor removal, untreated tumor disease, acute traumatic brain injury, and/or craniotomy
- (severe) dysarthria
- untreated hypertension exceeding 160/100 mmHg (patients with treated hypertension and blood pressure below 160/100 mmHg can be included)
- increased risk of vascular thrombosis
- epilepsy, photo sensitivity, acute focal findings (patients without focal findings or epileptiform discharges can be included when they had only a single seizure more than 10 years ago)
- dementias and neurodegenerative diseases
- significant psychiatric disturbances, e.g. schizophrenia
- major attention and/or memory deficits
- major hearing loss
- patients with uncorrected visual deficits
- severe global aphasia
- modality-specific disorders (pure speech apraxia, pure alexia, pure agraphia)
- electric or electronic implants (e.g. heart pacemakers)
- metal artefacts located at the head
- medication with impact on the central nervous system (e.g. antidepressant or sedative drugs)
- participation in another trial
- pregnant or breastfeeding women