Non-invasive Measurement of Cerebral Dynamic Autoregulation "TOMCAT"

Recruiting

Phase N/A Results N/A

Trial Description

The overall objective of this study is to evaluate the use of diffuse correlation spectroscopy to non-invasively measure dynamic cerebral autoregulation in subjects with vascular risk factors. Optical cerebral blood flow measurements will be correlated with changes in arterial blood pressure to assess how CBF is maintained in response to changes in ABP, and will be compared to transcranial doppler reference measurements.

Conditions

Interventions

  • Thigh Cuff Device
    ARM 1: Kind: Experimental
    Label: Intervention
    Description: We will measure dCA with both TCD and DCS during acute changes in mean arterial pressure using thigh cuff deflation techniques in vascular risk factor subjects. Measurements will be compared between TCD and DCS in order to validate DCS as a tool to measure dCA in this population.

Trial Design

  • Masking: Open Label
  • Endpoint: Safety/Efficacy Study
  • Intervention: Single Group Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary dCA measurement during acute changes in mean arterial pressure 1.5 hours No

Sponsors