Neuroregeneration Enhanced by Transcranial Direct Current Stimulation (TDCS) in Stroke "NETS"

Recruiting

Phase N/A Results N/A

Update History

24 Jun '17
The gender criteria for eligibility was updated to "All."
The eligibility criteria were updated.
New
Inclusion Criteria: - Subacute stroke patients (5-45 days after stroke, age>18 years) with thromboembolic non-hemorrhagic subcortical or cortical, clinically overt first-ever strokes will be included. Moderate to moderately severe upper-extremity hemiparesis, defined as an Upper Extremity Fugl-Meyer score (UEFMA) between 20 and 58 (inclusive). Exclusion Criteria: - pre-existing large lesions (> 1.5 cm maximum diameter in a brain area that belongs to the anatomically established sensorimotor/premotor system - progressive stroke - completely lesioned hand knob area of M1affected if no motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) are present - bilateral motoric impairment - florid alcohol and/or drug abuse - florid severe psychiatric illness (e.g. schizophrenia) - severe language disturbances that prevents the patient to give informed consent or inhibit adequate scoring because of insufficient understanding of scoring introductions - tumor diseases with a life expectancy less than one year - increased intracranial pressure - polyneuropathy and/or ischemic peripheral disease if the sensorimotor functions of the upper extremities are affected clinically relevant - severe cognitive deficits (MMSE ≤ 23) - pregnancy - contraindication for MRI or TMS
Old
Inclusion Criteria: - Subacute stroke patients (5-21 days after stroke, age>18 years) with thromboembolic non-hemorrhagic subcortical or cortical first-ever strokes will be included. Moderate to moderately severe upper-extremity hemiparesis, defined as an Upper Extremity Fugl-Meyer score (UEFMA) between 28 and 50 (inclusive). Exclusion Criteria: - more than one stroke - progressive stroke - completely lesioned hand knob area of M1affected or cerebellar lesions - history of severe alcohol or drug abuse, psychiatric illnesses like severe depression, poor motivational capacity, or severe language disturbances, or with serious cognitive deficits - severe uncontrolled medical problems - rheumatological or traumatic diseases affecting the upper extremities - other neurological diseases - severe microangiopathy, polyneuropathy, ischemic peripheral disease - pregnancy - contraindication for MRI or TMS
15 Sep '16
A location was updated in Bad Klosterlausnitz.
New
The overall status was updated to "Recruiting" at Moritz-Klinik Bad Klosterlausnitz.