Neuroregeneration Enhanced by Transcranial Direct Current Stimulation (TDCS) in Stroke "NETS"


Phase N/A Results N/A

Eligibility Criteria

Inclusion Criteria

- Subacute stroke patients (5-45 days after stroke, age>18 years) with thromboembolic non-hemorrhagic subcortical or cortical, clinically overt first-ever strokes will be included. Moderate to moderately severe upper-extremity hemiparesis, defined as an Upper Extremity Fugl-Meyer score (UEFMA) between 20 and 58 (inclusive).

Exclusion Criteria

- pre-existing large lesions (> 1.5 cm maximum diameter in a brain area that belongs to the anatomically established sensorimotor/premotor system
- progressive stroke
- completely lesioned hand knob area of M1affected if no motor evoked potentials (MEPs) elicited by transcranial magnetic stimulation (TMS) are present
- bilateral motoric impairment
- florid alcohol and/or drug abuse
- florid severe psychiatric illness (e.g. schizophrenia)
- severe language disturbances that prevents the patient to give informed consent or inhibit adequate scoring because of insufficient understanding of scoring introductions
- tumor diseases with a life expectancy less than one year
- increased intracranial pressure
- polyneuropathy and/or ischemic peripheral disease if the sensorimotor functions of the upper extremities are affected clinically relevant
- severe cognitive deficits (MMSE ≤ 23)
- pregnancy
- contraindication for MRI or TMS