Neuroplastic Change in Myelin of the Brain "Myelin"

Recruiting

Phase N/A Results N/A

Trial Description

The main goal of this research is to advance understanding of how stroke changes both the structure and function of the brain. The investigators will determine which is the key driver of recovery of arm function after stroke: changes in the structure of the brain or changes in how brain regions interact with one another.

Detailed Description

The main goal of this research is to advance understanding of how stroke changes both the structure and function of the brain. Further, the investigators will determine which is the key driver of recovery of arm function after stroke: changes in the structure of the brain or changes in how brain regions interact with one another. Together, these data will advance the investigators understanding of how neural systems support recovery from stroke. The investigators will use a MRI technique that allows us to assess the health of a brain structure called myelin. This structure is important as it allows information to travel down nerves faster; the more myelin the quicker the signal can be conducted. The investigators aim is to test whether or not movement training can restore myelin in the brain. If movement training does restore myelin in the brain, the investigators will have identified an important new target for rehabilitation interventions.

Conditions

Interventions

  • TRAIT Task Behavioral
    Intervention Desc: Increased paretic arm will be manipulated through the performance of a semi-immersive virtual reality-based intercept and release task called TRAIT (TRack And Intercept Task), which is performed in an interactive environment. TRAIT employs an open source Kinect sensor, which tracks 3-D joint movement. Participants are asked to control an on-screen icon using movements of their paretic arm to intercept a moving object as it emerges from the side of a computer screen. Once intercepted, they must accurately throw the object to hit a target. Participants move up through 10 levels of the game as their skill improves. Participants will complete 10 TRAIT training sessions in 4 weeks for a total of 10,000 experimental movements.
    ARM 1: Kind: Experimental
    Label: Stroke Group
    Description: Participants in the stroke group will complete 10 training sessions of the TRAIT task.
    ARM 2: Kind: Experimental
    Label: Matched Healthy Control Group
    Description: Participants in the Matched Healthy Control group will complete 10 sessions of the TRAIT task

Trial Design

  • Allocation: Non-Randomized
  • Masking: Single Blind (Outcomes Assessor)
  • Purpose: Basic Science
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Change in Myelin water fraction Baseline and 30 days post baseline No
Secondary Change in Fractional anisotropy Baseline and 30 days post baseline No

Sponsors