Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Induced Recovery

Active, not recruiting

Phase N/A Results N/A

Trial Description

The purpose of this study is to investigate the effects of treatment for specific language deficits in people with aphasia. In addition to language and cognitive measures, changes in brain function will also be gathered before and after the treatment is administered in order to track any changes resulting from receiving treatment.

Detailed Description

Naming Impairments (Anomia):
The labs of Dr. Swathi Kiran (Boston University) and Dr. David Caplan (Harvard University, Massachusetts General Hospital) will be studying language recovery in adults with anomia (naming impairments) following a stroke. Participants will receive treatment focusing on the semantic features of common objects (e.g., that birds can fly). The study will examine how naming and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Spelling/Writing Impairments (Dysgraphia):
At Johns Hopkins University, the lab of Dr. Brenda Rapp will investigate the neurobiology of language recovery in individuals with dysgraphia (spelling/writing impairments) resulting from a stroke. In this study, treatment will focus on improving spelling ability. The study will examine how spelling and other language abilities change in response to treatment, as well as how the brain changes, as measured by magnetic resonance imaging (MRI) and other techniques.
Deficits in Sentence Comprehension & Production:
Dr. Cynthia Thompson's lab at Northwestern University will investigate language recovery in individuals with deficits in sentence production and comprehension. Treatment focuses on production and comprehension of complex sentences. At baseline (week 0) and after the treatment period (at week 12), participants take part in language, eye-tracking, and MRI testing, in order to learn how the processing of language, as well as brain function, changes as a result of treatment.

Conditions

Interventions

  • No treatment Behavioral
    Intervention Desc: No treatment will be administered.
    ARM 1: Kind: Experimental
    Label: Naming Deficits
    Description: Language treatment will focus on improving naming deficits in people who have aphasia. An experimental group will receive treatment focusing on naming objects and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
    ARM 2: Kind: Experimental
    Label: Spelling and/or Writing Deficits
    Description: Language treatment will focus on improving writing and/or spelling deficits in people who have aphasia. An experimental group will receive treatment focusing on improving spelling abilities and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
    ARM 3: Kind: Experimental
    Label: Sentence Processing
    Description: Language treatment will focus on improving sentence comprehension and production deficits in people who have aphasia. An experimental group will receive treatment focusing on improving sentence processing and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
  • Treatment Focusing on Naming Objects Behavioral
    Other Names: Language treatment
    Intervention Desc: Treatment will be administered from week 0 until week 12.
    ARM 1: Kind: Experimental
    Label: Naming Deficits
    Description: Language treatment will focus on improving naming deficits in people who have aphasia. An experimental group will receive treatment focusing on naming objects and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
  • Treatment Focusing on Improving Spelling Abilities Behavioral
    Other Names: Language Treatment
    Intervention Desc: Treatment will be administered from week 0 until week 12.
    ARM 1: Kind: Experimental
    Label: Spelling and/or Writing Deficits
    Description: Language treatment will focus on improving writing and/or spelling deficits in people who have aphasia. An experimental group will receive treatment focusing on improving spelling abilities and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.
  • Treatment Focusing on Improving Sentence Processing Behavioral
    Other Names: Language Treatment
    Intervention Desc: Treatment will be administered from week 0 until week 12.
    ARM 1: Kind: Experimental
    Label: Sentence Processing
    Description: Language treatment will focus on improving sentence comprehension and production deficits in people who have aphasia. An experimental group will receive treatment focusing on improving sentence processing and a control/natural history group will receive no treatment. Both groups will be assessed at baseline (week 0), at week 12, and at week 24.

Trial Design

  • Allocation: Randomized
  • Masking: Open Label
  • Purpose: Treatment
  • Endpoint: Efficacy Study
  • Intervention: Parallel Assignment

Outcomes

Type Measure Time Frame Safety Issue
Primary Change in language and cognitive abilities as a result of treatment week 0 to week 12 No
Secondary Composite change in brain function as a result of treatment week 0 to week 12 No
Secondary Maintenance of language and cognitive abilities as a result of treatment week 12 to week 24 No
Secondary Maintenance of composite changes in brain function as a result of treatment week 12 to week 24 No

Sponsors