The aim of research to study therapeutic possibilities of navigation transcranial magnetic stimulation in stroke rehabilitation, finding optimal protocol.
Stroke is the main cause of long-term disability among adults. Disability following stroke results in significant impairment of patients quality of life. There was a lot of investigations with using Transcranial Magnetic Stimulation (TMS) as effective additional therapy in stroke rehabilitation. In this researches uses different protocols and patient's categories: high-frequency, low-frequency, etc. Using method of navigation transcranial magnetic stimulation with neuroimaging could help in choosing optimal protocol, assess effectiveness of therapy and forming prognosis.
- Transcranial Magnetic Stimulation Device
Intervention Desc: Transcranial magnetic stimulation is a noninvasive technique for including electrical currents in the cerebral cortex by means of time-varying magnetic fields. ARM 1: Kind: Experimental Label: Low-frequency stimulation Description: Stimulation mode: 1 Hz, 100% MT, 20 minutes, unaffected hemisphere ARM 2: Kind: Experimental Label: High frequency stimulation Description: Stimulation mode: 10 Hz, 80% MT, 2 seconds - stimulation, 58 seconds - rest. - 8 session; affected hemisphere ARM 3: Kind: Experimental Label: Sham stimulation Description: Patients will receive standard treatment (kinesotherapy, physiotherapy) and simulate of transcranial magnetic stimulation. Also patients will not know about simulation (blind group) ARM 4: Kind: Experimental Label: Both hemispheric stimulation Description: Stimulation mode: low-frequency to unaffected hemisphere than high-frequency to affected.
- Allocation: Randomized
- Masking: Single Blind (Subject)
- Purpose: Treatment
- Endpoint: Efficacy Study
- Intervention: Parallel Assignment
|Type||Measure||Time Frame||Safety Issue|
|Primary||Evidence of clinically definite ischemic stroke (focal neurological deficits persisting for more than 24 hours) confirmed by non-investigational CT or MRI||up to 20 days||Yes|
|Primary||The emergence of epileptic seizure||up to 20 days||Yes|
|Secondary||Evaluation of the clinical condition of the patient||up to 20 days||No|